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Vaccination against Lyme disease: past, present, and future

Lyme borreliosis is a zoonotic disease caused by Borrelia burgdorferi sensu lato bacteria transmitted to humans and domestic animals by the bite of an Ixodes spp. tick (deer tick). Despite improvements in diagnostic tests and public awareness of Lyme disease, the reported cases have increased over t...

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Autores principales: Embers, Monica E., Narasimhan, Sukanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569838/
https://www.ncbi.nlm.nih.gov/pubmed/23407755
http://dx.doi.org/10.3389/fcimb.2013.00006
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author Embers, Monica E.
Narasimhan, Sukanya
author_facet Embers, Monica E.
Narasimhan, Sukanya
author_sort Embers, Monica E.
collection PubMed
description Lyme borreliosis is a zoonotic disease caused by Borrelia burgdorferi sensu lato bacteria transmitted to humans and domestic animals by the bite of an Ixodes spp. tick (deer tick). Despite improvements in diagnostic tests and public awareness of Lyme disease, the reported cases have increased over the past decade to approximately 30,000 per year. Limitations and failed public acceptance of a human vaccine, comprised of the outer surface A (OspA) lipoprotein of B. burgdorferi, led to its demise, yet current research has opened doors to new strategies for protection against Lyme disease. In this review we discuss the enzootic cycle of B. burgdorferi, and the unique opportunities it poses to block infection or transmission at different levels. We present the correlates of protection for this infectious disease, the pros and cons of past vaccination strategies, and new paradigms for future vaccine design that would include elements of both the vector and the pathogen.
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spelling pubmed-35698382013-02-13 Vaccination against Lyme disease: past, present, and future Embers, Monica E. Narasimhan, Sukanya Front Cell Infect Microbiol Microbiology Lyme borreliosis is a zoonotic disease caused by Borrelia burgdorferi sensu lato bacteria transmitted to humans and domestic animals by the bite of an Ixodes spp. tick (deer tick). Despite improvements in diagnostic tests and public awareness of Lyme disease, the reported cases have increased over the past decade to approximately 30,000 per year. Limitations and failed public acceptance of a human vaccine, comprised of the outer surface A (OspA) lipoprotein of B. burgdorferi, led to its demise, yet current research has opened doors to new strategies for protection against Lyme disease. In this review we discuss the enzootic cycle of B. burgdorferi, and the unique opportunities it poses to block infection or transmission at different levels. We present the correlates of protection for this infectious disease, the pros and cons of past vaccination strategies, and new paradigms for future vaccine design that would include elements of both the vector and the pathogen. Frontiers Media S.A. 2013-02-12 /pmc/articles/PMC3569838/ /pubmed/23407755 http://dx.doi.org/10.3389/fcimb.2013.00006 Text en Copyright © 2013 Embers and Narasimhan. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Microbiology
Embers, Monica E.
Narasimhan, Sukanya
Vaccination against Lyme disease: past, present, and future
title Vaccination against Lyme disease: past, present, and future
title_full Vaccination against Lyme disease: past, present, and future
title_fullStr Vaccination against Lyme disease: past, present, and future
title_full_unstemmed Vaccination against Lyme disease: past, present, and future
title_short Vaccination against Lyme disease: past, present, and future
title_sort vaccination against lyme disease: past, present, and future
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569838/
https://www.ncbi.nlm.nih.gov/pubmed/23407755
http://dx.doi.org/10.3389/fcimb.2013.00006
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