A Review on JC Virus Infection in Kidney Transplant Recipients

The polyomavirus (PyV), JC virus (JCV), is a small nonenveloped DNA virus that asymptomatically infects about 80% of healthy adults and establishes latency in the kidney tissue. In case of immunodeficient hosts, JCV can lytically infect the oligodendrocytes, causing a fatal demyelinating disease, kn...

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Autores principales: Delbue, Serena, Ferraresso, Mariano, Ghio, Luciana, Carloni, Camilla, Carluccio, Silvia, Belingheri, Mirco, Edefonti, Alberto, Ferrante, Pasquale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569895/
https://www.ncbi.nlm.nih.gov/pubmed/23424601
http://dx.doi.org/10.1155/2013/926391
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author Delbue, Serena
Ferraresso, Mariano
Ghio, Luciana
Carloni, Camilla
Carluccio, Silvia
Belingheri, Mirco
Edefonti, Alberto
Ferrante, Pasquale
author_facet Delbue, Serena
Ferraresso, Mariano
Ghio, Luciana
Carloni, Camilla
Carluccio, Silvia
Belingheri, Mirco
Edefonti, Alberto
Ferrante, Pasquale
author_sort Delbue, Serena
collection PubMed
description The polyomavirus (PyV), JC virus (JCV), is a small nonenveloped DNA virus that asymptomatically infects about 80% of healthy adults and establishes latency in the kidney tissue. In case of immunodeficient hosts, JCV can lytically infect the oligodendrocytes, causing a fatal demyelinating disease, known as progressive multifocal leukoencephalopathy (PML). Although the reactivation of another human PyV, BK virus (BKV), is relatively common and its association with the polyomavirus associated nephropathy (PyVAN) following renal transplantation is proven, JCV replication and its impact on graft function and survival are less well studied. Here we describe the biology of JCV and its pathological features and we review the literature regarding the JCV infection analyzed in the setting of transplantations.
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spelling pubmed-35698952013-02-19 A Review on JC Virus Infection in Kidney Transplant Recipients Delbue, Serena Ferraresso, Mariano Ghio, Luciana Carloni, Camilla Carluccio, Silvia Belingheri, Mirco Edefonti, Alberto Ferrante, Pasquale Clin Dev Immunol Review Article The polyomavirus (PyV), JC virus (JCV), is a small nonenveloped DNA virus that asymptomatically infects about 80% of healthy adults and establishes latency in the kidney tissue. In case of immunodeficient hosts, JCV can lytically infect the oligodendrocytes, causing a fatal demyelinating disease, known as progressive multifocal leukoencephalopathy (PML). Although the reactivation of another human PyV, BK virus (BKV), is relatively common and its association with the polyomavirus associated nephropathy (PyVAN) following renal transplantation is proven, JCV replication and its impact on graft function and survival are less well studied. Here we describe the biology of JCV and its pathological features and we review the literature regarding the JCV infection analyzed in the setting of transplantations. Hindawi Publishing Corporation 2013 2013-01-29 /pmc/articles/PMC3569895/ /pubmed/23424601 http://dx.doi.org/10.1155/2013/926391 Text en Copyright © 2013 Serena Delbue et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Delbue, Serena
Ferraresso, Mariano
Ghio, Luciana
Carloni, Camilla
Carluccio, Silvia
Belingheri, Mirco
Edefonti, Alberto
Ferrante, Pasquale
A Review on JC Virus Infection in Kidney Transplant Recipients
title A Review on JC Virus Infection in Kidney Transplant Recipients
title_full A Review on JC Virus Infection in Kidney Transplant Recipients
title_fullStr A Review on JC Virus Infection in Kidney Transplant Recipients
title_full_unstemmed A Review on JC Virus Infection in Kidney Transplant Recipients
title_short A Review on JC Virus Infection in Kidney Transplant Recipients
title_sort review on jc virus infection in kidney transplant recipients
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569895/
https://www.ncbi.nlm.nih.gov/pubmed/23424601
http://dx.doi.org/10.1155/2013/926391
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