Insulin-Like Growth Factor 1 Receptor as a Therapeutic Target in Ewing Sarcoma: Lack of Consistent Upregulation or Recurrent Mutation and a Review of the Clinical Trial Literature

The insulin-like growth factor 1 receptor (IGF-1R) has been considered an important therapeutic target in Ewing sarcoma (ES), generating a need to identify the subset of patients most likely to respond to IGF-1R inhibitors. We assessed IGF-1R expression in ES cell lines and patient tumors to underst...

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Detalles Bibliográficos
Autores principales: O'Neill, Alison, Shah, Nilay, Zitomersky, Naamah, Ladanyi, Marc, Shukla, Neerav, Üren, Aykut, Loeb, David, Toretsky, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569907/
https://www.ncbi.nlm.nih.gov/pubmed/23431249
http://dx.doi.org/10.1155/2013/450478

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