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Development of Novel Bioanalytical Methods to Determine the Effective Concentrations of Phosphorodiamidate Morpholino Oligomers in Tissues and Cells

Phosphorodiamidate morpholino oligomers (PMO) are neutrally charged, sequence-specific antisense agents that interfere with targeted gene expression. PMO have been shown to be highly specific and potent therapies after cellular uptake, yet methods to detect PMO in tissue and inside the cell are limi...

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Detalles Bibliográficos
Autores principales:	Schnell, Frederick J., Crumley, Stacy L., Mourich, Dan V., Iversen, Patrick L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2013
Materias:	Technical Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569923/ https://www.ncbi.nlm.nih.gov/pubmed/23515175 http://dx.doi.org/10.1089/biores.2012.0276

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