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The NEDICES Study: Recent Advances in the Understanding of the Epidemiology of Essential Tremor
BACKGROUND: Essential tremor (ET) is the most common tremor disorder. ET has classically been viewed as a benign monosymptomatic condition. Yet over the past 10 years, a growing body of evidence indicates that this is a progressive condition that is clinically heterogeneous, and may be associated wi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Columbia University Libraries/Information Services
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570054/ https://www.ncbi.nlm.nih.gov/pubmed/23439396 |
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author | Romero, Juan Pablo Benito-León, Julián Bermejo-Pareja, Félix |
author_facet | Romero, Juan Pablo Benito-León, Julián Bermejo-Pareja, Félix |
author_sort | Romero, Juan Pablo |
collection | PubMed |
description | BACKGROUND: Essential tremor (ET) is the most common tremor disorder. ET has classically been viewed as a benign monosymptomatic condition. Yet over the past 10 years, a growing body of evidence indicates that this is a progressive condition that is clinically heterogeneous, and may be associated with a variety of different features. Large epidemiological studies such as the Neurological Disorders of Central Spain (NEDICES), a longitudinal, population-based survey, have contributed significantly to the changing view of the disease. Our aim is to review some of the main results of NEDICES within the larger framework of the epidemiology of ET. METHODS: Data for this review were gathered from all our articles published up to October 2011 regarding NEDICES study and “Essential Tremor”. RESULTS: We have published 18 articles up to October 2011. The prevalence, incidence, and mortality of ET were analyzed in this cohort. In addition, ET was found to be associated with increased frailty and low morale, as well as with a series of non-motor manifestations, including cognitive deficits, mild cognitive impairment, dementia, depressive symptoms, and hearing impairment. Finally, the link between ET and Parkinson's disease (PD) was formally quantified in the NEDICES study, which demonstrated that the risk of developing incident PD was 4.3 times higher in prevalent ET cases than in age-matched controls without ET. CONCLUSIONS: This review highlights the contributions of NEDICES towards the advancement of current knowledge of the epidemiology and clinical features of ET, and emphasizes the importance of population-based studies towards the understanding of complex, ageing-related diseases. |
format | Online Article Text |
id | pubmed-3570054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Columbia University Libraries/Information Services |
record_format | MEDLINE/PubMed |
spelling | pubmed-35700542013-02-25 The NEDICES Study: Recent Advances in the Understanding of the Epidemiology of Essential Tremor Romero, Juan Pablo Benito-León, Julián Bermejo-Pareja, Félix Tremor Other Hyperkinet Mov (N Y) Review BACKGROUND: Essential tremor (ET) is the most common tremor disorder. ET has classically been viewed as a benign monosymptomatic condition. Yet over the past 10 years, a growing body of evidence indicates that this is a progressive condition that is clinically heterogeneous, and may be associated with a variety of different features. Large epidemiological studies such as the Neurological Disorders of Central Spain (NEDICES), a longitudinal, population-based survey, have contributed significantly to the changing view of the disease. Our aim is to review some of the main results of NEDICES within the larger framework of the epidemiology of ET. METHODS: Data for this review were gathered from all our articles published up to October 2011 regarding NEDICES study and “Essential Tremor”. RESULTS: We have published 18 articles up to October 2011. The prevalence, incidence, and mortality of ET were analyzed in this cohort. In addition, ET was found to be associated with increased frailty and low morale, as well as with a series of non-motor manifestations, including cognitive deficits, mild cognitive impairment, dementia, depressive symptoms, and hearing impairment. Finally, the link between ET and Parkinson's disease (PD) was formally quantified in the NEDICES study, which demonstrated that the risk of developing incident PD was 4.3 times higher in prevalent ET cases than in age-matched controls without ET. CONCLUSIONS: This review highlights the contributions of NEDICES towards the advancement of current knowledge of the epidemiology and clinical features of ET, and emphasizes the importance of population-based studies towards the understanding of complex, ageing-related diseases. Columbia University Libraries/Information Services 2012-06-15 /pmc/articles/PMC3570054/ /pubmed/23439396 Text en http://creativecommons.org/licenses/by-nc-nd/3.0/us/ This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommerical–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original author and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed. |
spellingShingle | Review Romero, Juan Pablo Benito-León, Julián Bermejo-Pareja, Félix The NEDICES Study: Recent Advances in the Understanding of the Epidemiology of Essential Tremor |
title | The NEDICES Study: Recent Advances in the Understanding of the Epidemiology of Essential Tremor |
title_full | The NEDICES Study: Recent Advances in the Understanding of the Epidemiology of Essential Tremor |
title_fullStr | The NEDICES Study: Recent Advances in the Understanding of the Epidemiology of Essential Tremor |
title_full_unstemmed | The NEDICES Study: Recent Advances in the Understanding of the Epidemiology of Essential Tremor |
title_short | The NEDICES Study: Recent Advances in the Understanding of the Epidemiology of Essential Tremor |
title_sort | nedices study: recent advances in the understanding of the epidemiology of essential tremor |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570054/ https://www.ncbi.nlm.nih.gov/pubmed/23439396 |
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