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Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance
Macroautophagy serves cellular housekeeping and metabolic functions through delivery of cytoplasmic constituents for lysosomal degradation. In addition, it may mediate the unconventional presentation of intracellular antigens to CD4(+) T cells; however, the physiological relevance of this endogenous...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570095/ https://www.ncbi.nlm.nih.gov/pubmed/23382543 http://dx.doi.org/10.1084/jem.20122149 |