Erythropoietin-directed erythropoiesis depends on serpin inhibition of erythroblast lysosomal cathepsins

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Erythropoietin (EPO) and its cell surface receptor (EPOR) are essential for red blood cell production and exert important cytoprotective effects on select vascular, immune, and cancer cells. To discover novel EPO action modes, we profiled the transcriptome of primary erythroid progenitors. We report...

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Detalles Bibliográficos
Autores principales: Dev, Arvind, Byrne, Susan M., Verma, Rakesh, Ashton-Rickardt, Philip G., Wojchowski, Don M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570101/
https://www.ncbi.nlm.nih.gov/pubmed/23319700
http://dx.doi.org/10.1084/jem.20121762

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