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Helios marks strongly autoreactive CD4(+) T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB

Acquisition of self-tolerance in the thymus requires T cells to discriminate strong versus weak T cell receptor binding by self-peptide–MHC complexes. We find this discrimination is reported by expression of the transcription factor Helios, which is induced during negative selection but decreases du...

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Detalles Bibliográficos
Autores principales: Daley, Stephen R., Hu, Daniel Y., Goodnow, Christopher C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570102/
https://www.ncbi.nlm.nih.gov/pubmed/23337809
http://dx.doi.org/10.1084/jem.20121458