Loss of Function of the Mouse Sharpin Gene Results in Peyer’s Patch Regression

Peyer’s patches (PP) are an important component in the immune response against intestinal pathogens. Two independent, spontaneous mutations in the mouse Sharpin gene (Sharpin(cpdm) and Sharpin(cpdm-Dem)) result in the absence of PP and disrupted splenic white pulp in adult mice, although a full comp...

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Detalles Bibliográficos
Autores principales: Seymour, Rosemarie, Shirley, Bobbi-Jo, HogenEsch, Harm, Shultz, Leonard D., Sundberg, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570409/
https://www.ncbi.nlm.nih.gov/pubmed/23424624
http://dx.doi.org/10.1371/journal.pone.0055224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570409/
https://www.ncbi.nlm.nih.gov/pubmed/23424624
http://dx.doi.org/10.1371/journal.pone.0055224

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