RBC-NOS-Dependent S-Nitrosylation of Cytoskeletal Proteins Improves RBC Deformability

BACKGROUND: Red blood cells (RBC) possess a nitric oxide synthase (RBC-NOS) whose activation depends on the PI3-kinase/Akt kinase pathway. RBC-NOS-produced NO exhibits important biological functions like maintaining RBC deformability. Until now, the cellular target structure for NO, to exert its inf...

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Detalles Bibliográficos
Autores principales: Grau, Marijke, Pauly, Sebastian, Ali, Jamal, Walpurgis, Katja, Thevis, Mario, Bloch, Wilhelm, Suhr, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570529/
https://www.ncbi.nlm.nih.gov/pubmed/23424675
http://dx.doi.org/10.1371/journal.pone.0056759

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