Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes

TAL Effector Nucleases (TALENs) are versatile tools for targeted gene editing in various species. However, their efficiency is still insufficient, especially in mammalian embryos. Here, we showed that combined expression of Exonuclease 1 (Exo1) with engineered site-specific TALENs provided highly ef...

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Detalles Bibliográficos
Autores principales: Mashimo, Tomoji, Kaneko, Takehito, Sakuma, Tetsushi, Kobayashi, Junya, Kunihiro, Yayoi, Voigt, Birger, Yamamoto, Takashi, Serikawa, Tadao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570776/
https://www.ncbi.nlm.nih.gov/pubmed/23409244
http://dx.doi.org/10.1038/srep01253

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