Complete genome sequence of Treponema pallidum strain DAL-1

Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 whic...

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Detalles Bibliográficos
Autores principales: Zobaníková, Marie, Mikolka, Pavol, Čejková, Darina, Pospíšilová, Petra, Chen, Lei, Strouhal, Michal, Qin, Xiang, Weinstock, George M., Šmajs, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Michigan State University 2012
Materias:
Short Genome Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570794/
https://www.ncbi.nlm.nih.gov/pubmed/23449808
http://dx.doi.org/10.4056/sigs.2615838
Descripción
Sumario:Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing methods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain.

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