Complete genome sequence of Treponema pallidum strain DAL-1

Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 whic...

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Autores principales: Zobaníková, Marie, Mikolka, Pavol, Čejková, Darina, Pospíšilová, Petra, Chen, Lei, Strouhal, Michal, Qin, Xiang, Weinstock, George M., Šmajs, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Michigan State University 2012
Materias:
Short Genome Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570794/
https://www.ncbi.nlm.nih.gov/pubmed/23449808
http://dx.doi.org/10.4056/sigs.2615838
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author Zobaníková, Marie
Mikolka, Pavol
Čejková, Darina
Pospíšilová, Petra
Chen, Lei
Strouhal, Michal
Qin, Xiang
Weinstock, George M.
Šmajs, David
author_facet Zobaníková, Marie
Mikolka, Pavol
Čejková, Darina
Pospíšilová, Petra
Chen, Lei
Strouhal, Michal
Qin, Xiang
Weinstock, George M.
Šmajs, David
author_sort Zobaníková, Marie
collection PubMed
description Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing methods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain.
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spelling pubmed-35707942013-02-28 Complete genome sequence of Treponema pallidum strain DAL-1 Zobaníková, Marie Mikolka, Pavol Čejková, Darina Pospíšilová, Petra Chen, Lei Strouhal, Michal Qin, Xiang Weinstock, George M. Šmajs, David Stand Genomic Sci Short Genome Reports Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing methods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain. Michigan State University 2012-09-24 /pmc/articles/PMC3570794/ /pubmed/23449808 http://dx.doi.org/10.4056/sigs.2615838 Text en Copyright © retained by original authors. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Genome Reports
Zobaníková, Marie
Mikolka, Pavol
Čejková, Darina
Pospíšilová, Petra
Chen, Lei
Strouhal, Michal
Qin, Xiang
Weinstock, George M.
Šmajs, David
Complete genome sequence of Treponema pallidum strain DAL-1
title Complete genome sequence of Treponema pallidum strain DAL-1
title_full Complete genome sequence of Treponema pallidum strain DAL-1
title_fullStr Complete genome sequence of Treponema pallidum strain DAL-1
title_full_unstemmed Complete genome sequence of Treponema pallidum strain DAL-1
title_short Complete genome sequence of Treponema pallidum strain DAL-1
title_sort complete genome sequence of treponema pallidum strain dal-1
topic Short Genome Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570794/
https://www.ncbi.nlm.nih.gov/pubmed/23449808
http://dx.doi.org/10.4056/sigs.2615838
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