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Clonazepam as Agonist Substitution Treatment for Benzodiazepine Dependence: A Case Report
Nowadays, the misuse of benzodiazepines (BZDs) is a cause for a serious concern among pharmacologically inexperienced patients, whether treated or untreated, that could lead to significant complications, including tolerance, dependence, and addiction. We present a case report in which an Italian pat...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570932/ https://www.ncbi.nlm.nih.gov/pubmed/23424702 http://dx.doi.org/10.1155/2013/367594 |
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author | Maremmani, Angelo Giovanni Icro Rovai, Luca Rugani, Fabio Bacciardi, Silvia Pacini, Matteo Dell'Osso, Liliana Maremmani, Icro |
author_facet | Maremmani, Angelo Giovanni Icro Rovai, Luca Rugani, Fabio Bacciardi, Silvia Pacini, Matteo Dell'Osso, Liliana Maremmani, Icro |
author_sort | Maremmani, Angelo Giovanni Icro |
collection | PubMed |
description | Nowadays, the misuse of benzodiazepines (BZDs) is a cause for a serious concern among pharmacologically inexperienced patients, whether treated or untreated, that could lead to significant complications, including tolerance, dependence, and addiction. We present a case report in which an Italian patient affected by anxiety disorder and treated with BZDs presented a severe case of dependence on BZDs. We treated him according to an agonist substitution approach, switching from the abused BZD to a slow-onset, long-acting, high potency agonist (clonazepam), and looking at the methadone treatment model as paradigm. We decided to use clonazepam for its pharmacokinetic properties. The advantage of choosing a slow-onset, long-lasting BZD for the treatment of our patient was that it led us to a remarkable improvement in the clinical situation, including the cessation of craving, absence of withdrawal symptoms, reduced anxiety, improvements in social functioning, and a better cognition level. |
format | Online Article Text |
id | pubmed-3570932 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35709322013-02-19 Clonazepam as Agonist Substitution Treatment for Benzodiazepine Dependence: A Case Report Maremmani, Angelo Giovanni Icro Rovai, Luca Rugani, Fabio Bacciardi, Silvia Pacini, Matteo Dell'Osso, Liliana Maremmani, Icro Case Rep Psychiatry Case Report Nowadays, the misuse of benzodiazepines (BZDs) is a cause for a serious concern among pharmacologically inexperienced patients, whether treated or untreated, that could lead to significant complications, including tolerance, dependence, and addiction. We present a case report in which an Italian patient affected by anxiety disorder and treated with BZDs presented a severe case of dependence on BZDs. We treated him according to an agonist substitution approach, switching from the abused BZD to a slow-onset, long-acting, high potency agonist (clonazepam), and looking at the methadone treatment model as paradigm. We decided to use clonazepam for its pharmacokinetic properties. The advantage of choosing a slow-onset, long-lasting BZD for the treatment of our patient was that it led us to a remarkable improvement in the clinical situation, including the cessation of craving, absence of withdrawal symptoms, reduced anxiety, improvements in social functioning, and a better cognition level. Hindawi Publishing Corporation 2013 2013-01-30 /pmc/articles/PMC3570932/ /pubmed/23424702 http://dx.doi.org/10.1155/2013/367594 Text en Copyright © 2013 Angelo Giovanni Icro Maremmani et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Maremmani, Angelo Giovanni Icro Rovai, Luca Rugani, Fabio Bacciardi, Silvia Pacini, Matteo Dell'Osso, Liliana Maremmani, Icro Clonazepam as Agonist Substitution Treatment for Benzodiazepine Dependence: A Case Report |
title | Clonazepam as Agonist Substitution Treatment for Benzodiazepine Dependence: A Case Report |
title_full | Clonazepam as Agonist Substitution Treatment for Benzodiazepine Dependence: A Case Report |
title_fullStr | Clonazepam as Agonist Substitution Treatment for Benzodiazepine Dependence: A Case Report |
title_full_unstemmed | Clonazepam as Agonist Substitution Treatment for Benzodiazepine Dependence: A Case Report |
title_short | Clonazepam as Agonist Substitution Treatment for Benzodiazepine Dependence: A Case Report |
title_sort | clonazepam as agonist substitution treatment for benzodiazepine dependence: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570932/ https://www.ncbi.nlm.nih.gov/pubmed/23424702 http://dx.doi.org/10.1155/2013/367594 |
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