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Hyponatremia in traumatic brain injury patients: Syndrome of Inappropriate Antidiuretic Hormone (SIADH) versus Cerebral Salt Wasting Syndrome(CSWS)
BACKGROUND: Two common dysfunctions among traumatic brain injury (TBI) are hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and cerebral salt wasting syndrome (CSWS).The present study was aimed to define real incidence and most common cause of this probl...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kermanshah University of Medical Sciences
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571543/ |
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author | Sepehri, Parandoush Abbasi, Zahra Mohammadi, Najaf Seid Bagheri, Seyedreza Fattahian, Reza |
author_facet | Sepehri, Parandoush Abbasi, Zahra Mohammadi, Najaf Seid Bagheri, Seyedreza Fattahian, Reza |
author_sort | Sepehri, Parandoush |
collection | PubMed |
description | BACKGROUND: Two common dysfunctions among traumatic brain injury (TBI) are hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and cerebral salt wasting syndrome (CSWS).The present study was aimed to define real incidence and most common cause of this problem. Differentiation between these two syndromes is difficult because of overlapping signs, symptoms and specially laboratory data. Distinction between the two syndromes is based on patient's volume state. The present study aims to develop an alternative diagnosis strategy for defining the type of post-TBI hyponatremia. METHODS: This was a single-center retrospective study conducted on TBI diagnosed patients referred to intensive care unit (ICU) of Taleghani Hospital (Kermanshah, Iran). Hyponatremia condition is diagnosed when sodium level reaches the values of less than 135 meq/lit. Basic criterion for diagnosing the hyponatremia type was only urine volume. Urine volume was compared with previous days and fluid intake. If the volume showed a reduction, then the patient was classified in SIADH group, and the prescribed treatment was only fluid intake restriction. In cases of CSWS that have polyuric state and hyponatremia, treatment is sodium and fluid replacement. CBC, Na, K, FBS, BUN, Cr and urine 24-hour volume were measured daily, while during the treatment, it was performed twice or more. RESULTS: A total of 881 patients were referred to ICU during January 2011 to March 2012, of them, 678 patients had head trauma with and/or without other body injury. Out of all patients, 216 (%32) showed hyponatremia. Based on our diagnosis and treatment strategies, all of patient had lower urine output than previous day and were classified in the SIADH group and treated with only fluid restriction. None of patients were classified in CSWS group. All patients well recovered from hyponatremia with simple fluid restriction. In a clinical examination after a follow up period, the outcomes of all patients were acceptable with no adverse effects. CONCLUSIONS: Although CSWS was reported in many previous studies, the findings of the present study demonstrate that this procedure can be questioned and presence of CSWS following TBI is a rare condition, since it is probably an unpredictable response of kidney to stressor hormones. KEYWORDS: Hyponatremia, SIADH, CSWS, TBI |
format | Online Article Text |
id | pubmed-3571543 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Kermanshah University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-35715432013-03-19 Hyponatremia in traumatic brain injury patients: Syndrome of Inappropriate Antidiuretic Hormone (SIADH) versus Cerebral Salt Wasting Syndrome(CSWS) Sepehri, Parandoush Abbasi, Zahra Mohammadi, Najaf Seid Bagheri, Seyedreza Fattahian, Reza J Inj Violence Res Oral Presentation BACKGROUND: Two common dysfunctions among traumatic brain injury (TBI) are hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and cerebral salt wasting syndrome (CSWS).The present study was aimed to define real incidence and most common cause of this problem. Differentiation between these two syndromes is difficult because of overlapping signs, symptoms and specially laboratory data. Distinction between the two syndromes is based on patient's volume state. The present study aims to develop an alternative diagnosis strategy for defining the type of post-TBI hyponatremia. METHODS: This was a single-center retrospective study conducted on TBI diagnosed patients referred to intensive care unit (ICU) of Taleghani Hospital (Kermanshah, Iran). Hyponatremia condition is diagnosed when sodium level reaches the values of less than 135 meq/lit. Basic criterion for diagnosing the hyponatremia type was only urine volume. Urine volume was compared with previous days and fluid intake. If the volume showed a reduction, then the patient was classified in SIADH group, and the prescribed treatment was only fluid intake restriction. In cases of CSWS that have polyuric state and hyponatremia, treatment is sodium and fluid replacement. CBC, Na, K, FBS, BUN, Cr and urine 24-hour volume were measured daily, while during the treatment, it was performed twice or more. RESULTS: A total of 881 patients were referred to ICU during January 2011 to March 2012, of them, 678 patients had head trauma with and/or without other body injury. Out of all patients, 216 (%32) showed hyponatremia. Based on our diagnosis and treatment strategies, all of patient had lower urine output than previous day and were classified in the SIADH group and treated with only fluid restriction. None of patients were classified in CSWS group. All patients well recovered from hyponatremia with simple fluid restriction. In a clinical examination after a follow up period, the outcomes of all patients were acceptable with no adverse effects. CONCLUSIONS: Although CSWS was reported in many previous studies, the findings of the present study demonstrate that this procedure can be questioned and presence of CSWS following TBI is a rare condition, since it is probably an unpredictable response of kidney to stressor hormones. KEYWORDS: Hyponatremia, SIADH, CSWS, TBI Kermanshah University of Medical Sciences 2012-11 /pmc/articles/PMC3571543/ Text en Copyright © 2012, KUMS http://creativecommons.org/licenses/by/3/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Oral Presentation Sepehri, Parandoush Abbasi, Zahra Mohammadi, Najaf Seid Bagheri, Seyedreza Fattahian, Reza Hyponatremia in traumatic brain injury patients: Syndrome of Inappropriate Antidiuretic Hormone (SIADH) versus Cerebral Salt Wasting Syndrome(CSWS) |
title | Hyponatremia in traumatic brain injury patients: Syndrome of Inappropriate Antidiuretic Hormone (SIADH) versus Cerebral Salt Wasting Syndrome(CSWS) |
title_full | Hyponatremia in traumatic brain injury patients: Syndrome of Inappropriate Antidiuretic Hormone (SIADH) versus Cerebral Salt Wasting Syndrome(CSWS) |
title_fullStr | Hyponatremia in traumatic brain injury patients: Syndrome of Inappropriate Antidiuretic Hormone (SIADH) versus Cerebral Salt Wasting Syndrome(CSWS) |
title_full_unstemmed | Hyponatremia in traumatic brain injury patients: Syndrome of Inappropriate Antidiuretic Hormone (SIADH) versus Cerebral Salt Wasting Syndrome(CSWS) |
title_short | Hyponatremia in traumatic brain injury patients: Syndrome of Inappropriate Antidiuretic Hormone (SIADH) versus Cerebral Salt Wasting Syndrome(CSWS) |
title_sort | hyponatremia in traumatic brain injury patients: syndrome of inappropriate antidiuretic hormone (siadh) versus cerebral salt wasting syndrome(csws) |
topic | Oral Presentation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571543/ |
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