Cargando…
Label-Free Microcavity Biosensors: Steps towards Personalized Medicine
Personalized medicine has the potential to improve our ability to maintain health and treat disease, while ameliorating continuously rising healthcare costs. Translation of basic research findings to clinical applications within regulatory compliance is required for personalized medicine to become t...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571837/ https://www.ncbi.nlm.nih.gov/pubmed/23443397 http://dx.doi.org/10.3390/s121217262 |
_version_ | 1782259216291987456 |
---|---|
author | Amarie, Dragos Glazier, James A. |
author_facet | Amarie, Dragos Glazier, James A. |
author_sort | Amarie, Dragos |
collection | PubMed |
description | Personalized medicine has the potential to improve our ability to maintain health and treat disease, while ameliorating continuously rising healthcare costs. Translation of basic research findings to clinical applications within regulatory compliance is required for personalized medicine to become the new foundation for practice of medicine. Deploying even a few of the thousands of potential diagnostic biomarkers identified each year as part of personalized treatment workflows requires clinically efficient biosensor technologies to monitor multiple biomarkers in patients in real time. This paper discusses a critical component of a regulatory system, a microcavity optical biosensor for label-free monitoring of biomolecular interactions at physiologically-relevant concentrations. While most current biosensor research focuses on improving sensitivity, this paper emphasizes other characteristics a biosensor technology requires to be practical in a clinical setting, presenting robust microcavity biosensors which are easy to manufacture and integrate with microfluidics into flexible and redesignable platforms making the microcavity biosensors deployable for continuous monitoring of biomarkers in body fluids in the clinic, in dense 2D random arrays for high-throughput applications like drug-library screening in interactomics, and of the secretory behavior of single cells in the laboratory. |
format | Online Article Text |
id | pubmed-3571837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-35718372013-02-19 Label-Free Microcavity Biosensors: Steps towards Personalized Medicine Amarie, Dragos Glazier, James A. Sensors (Basel) Article Personalized medicine has the potential to improve our ability to maintain health and treat disease, while ameliorating continuously rising healthcare costs. Translation of basic research findings to clinical applications within regulatory compliance is required for personalized medicine to become the new foundation for practice of medicine. Deploying even a few of the thousands of potential diagnostic biomarkers identified each year as part of personalized treatment workflows requires clinically efficient biosensor technologies to monitor multiple biomarkers in patients in real time. This paper discusses a critical component of a regulatory system, a microcavity optical biosensor for label-free monitoring of biomolecular interactions at physiologically-relevant concentrations. While most current biosensor research focuses on improving sensitivity, this paper emphasizes other characteristics a biosensor technology requires to be practical in a clinical setting, presenting robust microcavity biosensors which are easy to manufacture and integrate with microfluidics into flexible and redesignable platforms making the microcavity biosensors deployable for continuous monitoring of biomarkers in body fluids in the clinic, in dense 2D random arrays for high-throughput applications like drug-library screening in interactomics, and of the secretory behavior of single cells in the laboratory. Molecular Diversity Preservation International (MDPI) 2012-12-13 /pmc/articles/PMC3571837/ /pubmed/23443397 http://dx.doi.org/10.3390/s121217262 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Amarie, Dragos Glazier, James A. Label-Free Microcavity Biosensors: Steps towards Personalized Medicine |
title | Label-Free Microcavity Biosensors: Steps towards Personalized Medicine |
title_full | Label-Free Microcavity Biosensors: Steps towards Personalized Medicine |
title_fullStr | Label-Free Microcavity Biosensors: Steps towards Personalized Medicine |
title_full_unstemmed | Label-Free Microcavity Biosensors: Steps towards Personalized Medicine |
title_short | Label-Free Microcavity Biosensors: Steps towards Personalized Medicine |
title_sort | label-free microcavity biosensors: steps towards personalized medicine |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571837/ https://www.ncbi.nlm.nih.gov/pubmed/23443397 http://dx.doi.org/10.3390/s121217262 |
work_keys_str_mv | AT amariedragos labelfreemicrocavitybiosensorsstepstowardspersonalizedmedicine AT glazierjamesa labelfreemicrocavitybiosensorsstepstowardspersonalizedmedicine |