Cargando…

Label-Free Microcavity Biosensors: Steps towards Personalized Medicine

Personalized medicine has the potential to improve our ability to maintain health and treat disease, while ameliorating continuously rising healthcare costs. Translation of basic research findings to clinical applications within regulatory compliance is required for personalized medicine to become t...

Descripción completa

Detalles Bibliográficos
Autores principales: Amarie, Dragos, Glazier, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571837/
https://www.ncbi.nlm.nih.gov/pubmed/23443397
http://dx.doi.org/10.3390/s121217262
_version_ 1782259216291987456
author Amarie, Dragos
Glazier, James A.
author_facet Amarie, Dragos
Glazier, James A.
author_sort Amarie, Dragos
collection PubMed
description Personalized medicine has the potential to improve our ability to maintain health and treat disease, while ameliorating continuously rising healthcare costs. Translation of basic research findings to clinical applications within regulatory compliance is required for personalized medicine to become the new foundation for practice of medicine. Deploying even a few of the thousands of potential diagnostic biomarkers identified each year as part of personalized treatment workflows requires clinically efficient biosensor technologies to monitor multiple biomarkers in patients in real time. This paper discusses a critical component of a regulatory system, a microcavity optical biosensor for label-free monitoring of biomolecular interactions at physiologically-relevant concentrations. While most current biosensor research focuses on improving sensitivity, this paper emphasizes other characteristics a biosensor technology requires to be practical in a clinical setting, presenting robust microcavity biosensors which are easy to manufacture and integrate with microfluidics into flexible and redesignable platforms making the microcavity biosensors deployable for continuous monitoring of biomarkers in body fluids in the clinic, in dense 2D random arrays for high-throughput applications like drug-library screening in interactomics, and of the secretory behavior of single cells in the laboratory.
format Online
Article
Text
id pubmed-3571837
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-35718372013-02-19 Label-Free Microcavity Biosensors: Steps towards Personalized Medicine Amarie, Dragos Glazier, James A. Sensors (Basel) Article Personalized medicine has the potential to improve our ability to maintain health and treat disease, while ameliorating continuously rising healthcare costs. Translation of basic research findings to clinical applications within regulatory compliance is required for personalized medicine to become the new foundation for practice of medicine. Deploying even a few of the thousands of potential diagnostic biomarkers identified each year as part of personalized treatment workflows requires clinically efficient biosensor technologies to monitor multiple biomarkers in patients in real time. This paper discusses a critical component of a regulatory system, a microcavity optical biosensor for label-free monitoring of biomolecular interactions at physiologically-relevant concentrations. While most current biosensor research focuses on improving sensitivity, this paper emphasizes other characteristics a biosensor technology requires to be practical in a clinical setting, presenting robust microcavity biosensors which are easy to manufacture and integrate with microfluidics into flexible and redesignable platforms making the microcavity biosensors deployable for continuous monitoring of biomarkers in body fluids in the clinic, in dense 2D random arrays for high-throughput applications like drug-library screening in interactomics, and of the secretory behavior of single cells in the laboratory. Molecular Diversity Preservation International (MDPI) 2012-12-13 /pmc/articles/PMC3571837/ /pubmed/23443397 http://dx.doi.org/10.3390/s121217262 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Amarie, Dragos
Glazier, James A.
Label-Free Microcavity Biosensors: Steps towards Personalized Medicine
title Label-Free Microcavity Biosensors: Steps towards Personalized Medicine
title_full Label-Free Microcavity Biosensors: Steps towards Personalized Medicine
title_fullStr Label-Free Microcavity Biosensors: Steps towards Personalized Medicine
title_full_unstemmed Label-Free Microcavity Biosensors: Steps towards Personalized Medicine
title_short Label-Free Microcavity Biosensors: Steps towards Personalized Medicine
title_sort label-free microcavity biosensors: steps towards personalized medicine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571837/
https://www.ncbi.nlm.nih.gov/pubmed/23443397
http://dx.doi.org/10.3390/s121217262
work_keys_str_mv AT amariedragos labelfreemicrocavitybiosensorsstepstowardspersonalizedmedicine
AT glazierjamesa labelfreemicrocavitybiosensorsstepstowardspersonalizedmedicine