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Novel methods for quantifying individual host response to infectious pathogens for genetic analyses

We propose two novel approaches for describing and quantifying the response of individual hosts to pathogen challenge in terms of infection severity and impact on host performance. The first approach is a direct extension of the methodology for estimating group tolerance (the change in performance w...

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Autores principales: Doeschl-Wilson, Andrea B., Bishop, Steve C., Kyriazakis, Ilias, Villanueva, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571862/
https://www.ncbi.nlm.nih.gov/pubmed/23413235
http://dx.doi.org/10.3389/fgene.2012.00266
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author Doeschl-Wilson, Andrea B.
Bishop, Steve C.
Kyriazakis, Ilias
Villanueva, Beatriz
author_facet Doeschl-Wilson, Andrea B.
Bishop, Steve C.
Kyriazakis, Ilias
Villanueva, Beatriz
author_sort Doeschl-Wilson, Andrea B.
collection PubMed
description We propose two novel approaches for describing and quantifying the response of individual hosts to pathogen challenge in terms of infection severity and impact on host performance. The first approach is a direct extension of the methodology for estimating group tolerance (the change in performance with respect to changes in pathogen burden in a host population) to the level of individuals. The second approach aims to capture the dynamic aspects of individual resistance and tolerance over the entire time course of infections. In contrast to the first approach, which provides a means to disentangle host resistance from tolerance, the second approach focuses on the combined effects of both characteristics. Both approaches provide new individual phenotypes for subsequent genetic analyses and come with specific data requirements. In particular, both approaches rely on the availability of repeated performance and pathogen burden measurements of individuals over the time course of one or several episodes of infection. Consideration of individual tolerance also highlights some of the assumptions hidden within the concept of group tolerance, indicating where care needs to be taken in trait definition and measurement.
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spelling pubmed-35718622013-02-14 Novel methods for quantifying individual host response to infectious pathogens for genetic analyses Doeschl-Wilson, Andrea B. Bishop, Steve C. Kyriazakis, Ilias Villanueva, Beatriz Front Genet Genetics We propose two novel approaches for describing and quantifying the response of individual hosts to pathogen challenge in terms of infection severity and impact on host performance. The first approach is a direct extension of the methodology for estimating group tolerance (the change in performance with respect to changes in pathogen burden in a host population) to the level of individuals. The second approach aims to capture the dynamic aspects of individual resistance and tolerance over the entire time course of infections. In contrast to the first approach, which provides a means to disentangle host resistance from tolerance, the second approach focuses on the combined effects of both characteristics. Both approaches provide new individual phenotypes for subsequent genetic analyses and come with specific data requirements. In particular, both approaches rely on the availability of repeated performance and pathogen burden measurements of individuals over the time course of one or several episodes of infection. Consideration of individual tolerance also highlights some of the assumptions hidden within the concept of group tolerance, indicating where care needs to be taken in trait definition and measurement. Frontiers Media S.A. 2012-12-14 /pmc/articles/PMC3571862/ /pubmed/23413235 http://dx.doi.org/10.3389/fgene.2012.00266 Text en Copyright © 2012 Doeschl-Wilson, Bishop, Kyriazakis and Villanueva. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Genetics
Doeschl-Wilson, Andrea B.
Bishop, Steve C.
Kyriazakis, Ilias
Villanueva, Beatriz
Novel methods for quantifying individual host response to infectious pathogens for genetic analyses
title Novel methods for quantifying individual host response to infectious pathogens for genetic analyses
title_full Novel methods for quantifying individual host response to infectious pathogens for genetic analyses
title_fullStr Novel methods for quantifying individual host response to infectious pathogens for genetic analyses
title_full_unstemmed Novel methods for quantifying individual host response to infectious pathogens for genetic analyses
title_short Novel methods for quantifying individual host response to infectious pathogens for genetic analyses
title_sort novel methods for quantifying individual host response to infectious pathogens for genetic analyses
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571862/
https://www.ncbi.nlm.nih.gov/pubmed/23413235
http://dx.doi.org/10.3389/fgene.2012.00266
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