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Compare and contrast the reaction coordinate diagrams for chemical reactions and cytoskeletal force generators

Reaction coordinate diagrams are used to relate the free energy changes that occur during the progress of chemical processes to the rate and equilibrium constants of the process. Here I briefly review the application of these diagrams to the thermodynamics and kinetics of the generation of force and...

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Autor principal: Scholey, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571866/
https://www.ncbi.nlm.nih.gov/pubmed/23408787
http://dx.doi.org/10.1091/mbc.E12-07-0545
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author Scholey, Jonathan M.
author_facet Scholey, Jonathan M.
author_sort Scholey, Jonathan M.
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description Reaction coordinate diagrams are used to relate the free energy changes that occur during the progress of chemical processes to the rate and equilibrium constants of the process. Here I briefly review the application of these diagrams to the thermodynamics and kinetics of the generation of force and motion by cytoskeletal motors and polymer ratchets as they mediate intracellular transport, organelle dynamics, cell locomotion, and cell division. To provide a familiar biochemical context for discussing these subcellular force generators, I first review the application of reaction coordinate diagrams to the mechanisms of simple chemical and enzyme-catalyzed reactions. My description of reaction coordinate diagrams of motors and polymer ratchets is simplified relative to the rigorous biophysical treatment found in many of the references that I use and cite, but I hope that the essay provides a valuable qualitative representation of the physical chemical parameters that underlie the generation of force and motility at molecular scales. In any case, I have found that this approach represents a useful interdisciplinary framework for understanding, researching, and teaching the basic molecular mechanisms by which motors contribute to fundamental cell biological processes.
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spelling pubmed-35718662013-04-30 Compare and contrast the reaction coordinate diagrams for chemical reactions and cytoskeletal force generators Scholey, Jonathan M. Mol Biol Cell Perspective Reaction coordinate diagrams are used to relate the free energy changes that occur during the progress of chemical processes to the rate and equilibrium constants of the process. Here I briefly review the application of these diagrams to the thermodynamics and kinetics of the generation of force and motion by cytoskeletal motors and polymer ratchets as they mediate intracellular transport, organelle dynamics, cell locomotion, and cell division. To provide a familiar biochemical context for discussing these subcellular force generators, I first review the application of reaction coordinate diagrams to the mechanisms of simple chemical and enzyme-catalyzed reactions. My description of reaction coordinate diagrams of motors and polymer ratchets is simplified relative to the rigorous biophysical treatment found in many of the references that I use and cite, but I hope that the essay provides a valuable qualitative representation of the physical chemical parameters that underlie the generation of force and motility at molecular scales. In any case, I have found that this approach represents a useful interdisciplinary framework for understanding, researching, and teaching the basic molecular mechanisms by which motors contribute to fundamental cell biological processes. The American Society for Cell Biology 2013-02-15 /pmc/articles/PMC3571866/ /pubmed/23408787 http://dx.doi.org/10.1091/mbc.E12-07-0545 Text en © 2013 Scholey. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell BD; are registered trademarks of The American Society of Cell Biology.
spellingShingle Perspective
Scholey, Jonathan M.
Compare and contrast the reaction coordinate diagrams for chemical reactions and cytoskeletal force generators
title Compare and contrast the reaction coordinate diagrams for chemical reactions and cytoskeletal force generators
title_full Compare and contrast the reaction coordinate diagrams for chemical reactions and cytoskeletal force generators
title_fullStr Compare and contrast the reaction coordinate diagrams for chemical reactions and cytoskeletal force generators
title_full_unstemmed Compare and contrast the reaction coordinate diagrams for chemical reactions and cytoskeletal force generators
title_short Compare and contrast the reaction coordinate diagrams for chemical reactions and cytoskeletal force generators
title_sort compare and contrast the reaction coordinate diagrams for chemical reactions and cytoskeletal force generators
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571866/
https://www.ncbi.nlm.nih.gov/pubmed/23408787
http://dx.doi.org/10.1091/mbc.E12-07-0545
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