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β-Catenin–dependent lysosomal targeting of internalized tumor necrosis factor-α suppresses caspase-8 activation in apoptosis-resistant colon cancer cells

The Wnt/β-catenin pathway is constitutively activated in more than 90% of human colorectal cancer. Activated β-catenin stimulates cell proliferation and survival, however, its antiapoptotic mechanisms are not fully understood. We show here that activated β-catenin is required to suppress caspase-8 a...

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Detalles Bibliográficos
Autores principales:	Han, Jinbo, Sridevi, Priya, Ramirez, Michael, Ludwig, Kirsten J., Wang, Jean Y. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571869/ https://www.ncbi.nlm.nih.gov/pubmed/23264463 http://dx.doi.org/10.1091/mbc.E12-09-0662

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