M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding

BACKGROUND: HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen. FINDINGS: To address this problem, here, we report that pretreatment of HIV-infected peri...

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Autores principales: Selhorst, Philippe, Grupping, Katrijn, Tong, Tommy, Crooks, Ema T, Martin, Loïc, Vanham, Guido, Binley, James M, Ariën, Kevin K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571899/
https://www.ncbi.nlm.nih.gov/pubmed/23375046
http://dx.doi.org/10.1186/1742-4690-10-12
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author Selhorst, Philippe
Grupping, Katrijn
Tong, Tommy
Crooks, Ema T
Martin, Loïc
Vanham, Guido
Binley, James M
Ariën, Kevin K
author_facet Selhorst, Philippe
Grupping, Katrijn
Tong, Tommy
Crooks, Ema T
Martin, Loïc
Vanham, Guido
Binley, James M
Ariën, Kevin K
author_sort Selhorst, Philippe
collection PubMed
description BACKGROUND: HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen. FINDINGS: To address this problem, here, we report that pretreatment of HIV-infected peripheral blood mononuclear cells (PBMCs) with a 27 amino acid CD4-mimetic, M48U1, causes dramatic and prolonged reduction of infectious virus output, due to its induction of gp120 shedding. CONCLUSIONS: M48U1 may, therefore, be valuable for prophylaxis of mucosal HIV-1 transmission.
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spelling pubmed-35718992013-02-14 M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding Selhorst, Philippe Grupping, Katrijn Tong, Tommy Crooks, Ema T Martin, Loïc Vanham, Guido Binley, James M Ariën, Kevin K Retrovirology Short Report BACKGROUND: HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen. FINDINGS: To address this problem, here, we report that pretreatment of HIV-infected peripheral blood mononuclear cells (PBMCs) with a 27 amino acid CD4-mimetic, M48U1, causes dramatic and prolonged reduction of infectious virus output, due to its induction of gp120 shedding. CONCLUSIONS: M48U1 may, therefore, be valuable for prophylaxis of mucosal HIV-1 transmission. BioMed Central 2013-02-01 /pmc/articles/PMC3571899/ /pubmed/23375046 http://dx.doi.org/10.1186/1742-4690-10-12 Text en Copyright ©2013 Selhorst et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Selhorst, Philippe
Grupping, Katrijn
Tong, Tommy
Crooks, Ema T
Martin, Loïc
Vanham, Guido
Binley, James M
Ariën, Kevin K
M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
title M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
title_full M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
title_fullStr M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
title_full_unstemmed M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
title_short M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
title_sort m48u1 cd4 mimetic has a sustained inhibitory effect on cell-associated hiv-1 by attenuating virion infectivity through gp120 shedding
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571899/
https://www.ncbi.nlm.nih.gov/pubmed/23375046
http://dx.doi.org/10.1186/1742-4690-10-12
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