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Increased Tau Phosphorylation and Tau Truncation, and Decreased Synaptophysin Levels in Mutant BRI(2)/Tau Transgenic Mice

Familial Danish dementia (FDD) is an autosomal dominant neurodegenerative disease caused by a 10-nucleotide duplication-insertion in the BRI(2) gene. FDD is clinically characterized by loss of vision, hearing impairment, cerebellar ataxia and dementia. The main neuropathologic findings in FDD are th...

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Detalles Bibliográficos
Autores principales:	Garringer, Holly J., Murrell, Jill, Sammeta, Neeraja, Gnezda, Anita, Ghetti, Bernardino, Vidal, Ruben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572042/ https://www.ncbi.nlm.nih.gov/pubmed/23418567 http://dx.doi.org/10.1371/journal.pone.0056426

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