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Characteristics of Randomized Trials Published in Latin America and the Caribbean According to Funding Source

INTRODUCTION: Few studies have assessed the nature and quality of randomized controlled trials (RCTs) in Latin America and the Caribbean (LAC). METHODS AND FINDINGS: The aims of this systematic review are to evaluate the characteristics (including the risk of bias assessment) of RCT conducted in LAC...

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Autores principales: Reveiz, Ludovic, Sangalang, Stephanie, Glujovsky, Demian, Pinzon, Carlos E., Asenjo Lobos, Claudia, Cortes, Marcela, Cañón, Martin, Bardach, Ariel, Bonfill, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572054/
https://www.ncbi.nlm.nih.gov/pubmed/23418566
http://dx.doi.org/10.1371/journal.pone.0056410
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author Reveiz, Ludovic
Sangalang, Stephanie
Glujovsky, Demian
Pinzon, Carlos E.
Asenjo Lobos, Claudia
Cortes, Marcela
Cañón, Martin
Bardach, Ariel
Bonfill, Xavier
author_facet Reveiz, Ludovic
Sangalang, Stephanie
Glujovsky, Demian
Pinzon, Carlos E.
Asenjo Lobos, Claudia
Cortes, Marcela
Cañón, Martin
Bardach, Ariel
Bonfill, Xavier
author_sort Reveiz, Ludovic
collection PubMed
description INTRODUCTION: Few studies have assessed the nature and quality of randomized controlled trials (RCTs) in Latin America and the Caribbean (LAC). METHODS AND FINDINGS: The aims of this systematic review are to evaluate the characteristics (including the risk of bias assessment) of RCT conducted in LAC according to funding source. A review of RCTs published in 2010 in which the author's affiliation was from LAC was performed in PubMed and LILACS. Two reviewers independently extracted data and assessed the risk of bias. The primary outcomes were risk of bias assessment and funding source. A total of 1,695 references were found in PubMed and LILACS databases, of which 526 were RCTs (N = 73.513 participants). English was the dominant publication language (93%) and most of the RCTs were published in non-LAC journals (84.2%). Only five of the 19 identified countries accounted for nearly 95% of all RCTs conducted in the region (Brazil 70.9%, Mexico 10.1%, Argentina 5.9%, Colombia 3.8%, and Chile 3.4%). Few RCTs covered priority areas related with Millennium Development Goals like maternal health (6.7%) or high priority infectious diseases (3.8%). Regarding children, 3.6% and 0.4% RCT evaluated nutrition and diarrhea interventions respectively but none pneumonia. As a comparison, aesthetic and sport related interventions account for 4.6% of all trials. A random sample of RCTs (n = 358) was assessed for funding source: exclusively public (33.8%); private (e.g. pharmaceutical company) (15.3%); other (e.g. mixed, NGO) (15.1%); no funding (35.8%). Overall assessments for risk of bias showed no statistically significant differences between RCTs and type of funding source. Statistically significant differences favoring private and others type of funding was found when assessing trial registration and conflict of interest reporting. CONCLUSION: Findings of this study could be used to provide more direction for future research to facilitate innovation, improve health outcomes or address priority health problems.
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spelling pubmed-35720542013-02-15 Characteristics of Randomized Trials Published in Latin America and the Caribbean According to Funding Source Reveiz, Ludovic Sangalang, Stephanie Glujovsky, Demian Pinzon, Carlos E. Asenjo Lobos, Claudia Cortes, Marcela Cañón, Martin Bardach, Ariel Bonfill, Xavier PLoS One Research Article INTRODUCTION: Few studies have assessed the nature and quality of randomized controlled trials (RCTs) in Latin America and the Caribbean (LAC). METHODS AND FINDINGS: The aims of this systematic review are to evaluate the characteristics (including the risk of bias assessment) of RCT conducted in LAC according to funding source. A review of RCTs published in 2010 in which the author's affiliation was from LAC was performed in PubMed and LILACS. Two reviewers independently extracted data and assessed the risk of bias. The primary outcomes were risk of bias assessment and funding source. A total of 1,695 references were found in PubMed and LILACS databases, of which 526 were RCTs (N = 73.513 participants). English was the dominant publication language (93%) and most of the RCTs were published in non-LAC journals (84.2%). Only five of the 19 identified countries accounted for nearly 95% of all RCTs conducted in the region (Brazil 70.9%, Mexico 10.1%, Argentina 5.9%, Colombia 3.8%, and Chile 3.4%). Few RCTs covered priority areas related with Millennium Development Goals like maternal health (6.7%) or high priority infectious diseases (3.8%). Regarding children, 3.6% and 0.4% RCT evaluated nutrition and diarrhea interventions respectively but none pneumonia. As a comparison, aesthetic and sport related interventions account for 4.6% of all trials. A random sample of RCTs (n = 358) was assessed for funding source: exclusively public (33.8%); private (e.g. pharmaceutical company) (15.3%); other (e.g. mixed, NGO) (15.1%); no funding (35.8%). Overall assessments for risk of bias showed no statistically significant differences between RCTs and type of funding source. Statistically significant differences favoring private and others type of funding was found when assessing trial registration and conflict of interest reporting. CONCLUSION: Findings of this study could be used to provide more direction for future research to facilitate innovation, improve health outcomes or address priority health problems. Public Library of Science 2013-02-13 /pmc/articles/PMC3572054/ /pubmed/23418566 http://dx.doi.org/10.1371/journal.pone.0056410 Text en © 2013 Reveiz et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Reveiz, Ludovic
Sangalang, Stephanie
Glujovsky, Demian
Pinzon, Carlos E.
Asenjo Lobos, Claudia
Cortes, Marcela
Cañón, Martin
Bardach, Ariel
Bonfill, Xavier
Characteristics of Randomized Trials Published in Latin America and the Caribbean According to Funding Source
title Characteristics of Randomized Trials Published in Latin America and the Caribbean According to Funding Source
title_full Characteristics of Randomized Trials Published in Latin America and the Caribbean According to Funding Source
title_fullStr Characteristics of Randomized Trials Published in Latin America and the Caribbean According to Funding Source
title_full_unstemmed Characteristics of Randomized Trials Published in Latin America and the Caribbean According to Funding Source
title_short Characteristics of Randomized Trials Published in Latin America and the Caribbean According to Funding Source
title_sort characteristics of randomized trials published in latin america and the caribbean according to funding source
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572054/
https://www.ncbi.nlm.nih.gov/pubmed/23418566
http://dx.doi.org/10.1371/journal.pone.0056410
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