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Absence of Nrf2 or Its Selective Overexpression in Neurons and Muscle Does Not Affect Survival in ALS-Linked Mutant hSOD1 Mouse Models

The nuclear factor erythroid 2-related factor 2 (Nrf2) governs the expression of antioxidant and phase II detoxifying enzymes. Nrf2 activation can prevent or reduce cellular damage associated with several types of injury in many different tissues and organs. Dominant mutations in Cu/Zn-superoxide di...

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Detalles Bibliográficos
Autores principales:	Vargas, Marcelo R., Burton, Neal C., Gan, Li, Johnson, Delinda A., Schäfer, Matthias, Werner, Sabine, Johnson, Jeffrey A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572065/ https://www.ncbi.nlm.nih.gov/pubmed/23418589 http://dx.doi.org/10.1371/journal.pone.0056625

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