Targeting the Shift from M1 to M2 Macrophages in Experimental Autoimmune Encephalomyelitis Mice Treated with Fasudil

We observed the therapeutic effect of Fasudil and explored its mechanisms in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Fasudil, a selective Rho kinase (ROCK) inhibitor, was injected intraperitoneally at 40 mg/kg/d in early and late stages of EAE ind...

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Detalles Bibliográficos
Autores principales: Liu, Chunyun, Li, Yanhua, Yu, Jiezhong, Feng, Ling, Hou, Shaowei, Liu, Yueting, Guo, Mingfang, Xie, Yong, Meng, Jian, Zhang, Haifei, Xiao, Baoguo, Ma, Cungen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572131/
https://www.ncbi.nlm.nih.gov/pubmed/23418431
http://dx.doi.org/10.1371/journal.pone.0054841

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