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Suppression of LFA-1 Expression by Spermine Is Associated with Enhanced Methylation of ITGAL, the LFA-1 Promoter Area

Spermine and spermidine, natural polyamines, suppress lymphocyte function-associated antigen 1 (LFA-1) expression and its associated cellular functions through mechanisms that remain unknown. Inhibition of ornithine decarboxylase, which is required for polyamine synthesis, in Jurkat cells by 3 mM D,...

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Detalles Bibliográficos
Autores principales:	Kano, Yoshihiko, Soda, Kuniyasu, Konishi, Fumio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572138/ https://www.ncbi.nlm.nih.gov/pubmed/23418509 http://dx.doi.org/10.1371/journal.pone.0056056

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