Inhibition of Glycogen Synthase Kinase 3β Promotes Tight Junction Stability in Brain Endothelial Cells by Half-Life Extension of Occludin and Claudin-5

Neuroinflammatory conditions often involve dysfunction of the Blood-Brain Barrier (BBB). Therefore, identifying molecular targets that can maintain barrier fidelity is of clinical importance. We have previously reported on the anti-inflammatory effects that glycogen synthase kinase 3β (GSK3β) inhibi...

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Detalles Bibliográficos
Autores principales: Ramirez, Servio H., Fan, Shongshan, Dykstra, Holly, Rom, Slava, Mercer, Aaron, Reichenbach, Nancy L., Gofman, Larisa, Persidsky, Yuri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572160/
https://www.ncbi.nlm.nih.gov/pubmed/23418486
http://dx.doi.org/10.1371/journal.pone.0055972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572160/
https://www.ncbi.nlm.nih.gov/pubmed/23418486
http://dx.doi.org/10.1371/journal.pone.0055972

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