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Maternal and Pregnancy Related Predictors of Cardiometabolic Traits in Newborns

BACKGROUND: The influence of multiple maternal and pregnancy characteristics on offspring cardiometabolic traits at birth is not well understood and was evaluated in this study. METHODS AND FINDINGS: The Family Atherosclerosis Monitoring In earLY life (FAMILY) Study prospectively evaluated 11 cardio...

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Autores principales: Morrison, Katherine M., Anand, Sonia S., Yusuf, Salim, Atkinson, Stephanie A., Schulze, Karleen M., Rao-Melacini, Purnima, McQueen, Matthew J., McDonald, Sarah, Persadie, Richard, Hunter, Barry, Bourgeois, Jacqueline, Jansen, Jan W., Teo, Koon K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572188/
https://www.ncbi.nlm.nih.gov/pubmed/23418462
http://dx.doi.org/10.1371/journal.pone.0055815
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author Morrison, Katherine M.
Anand, Sonia S.
Yusuf, Salim
Atkinson, Stephanie A.
Schulze, Karleen M.
Rao-Melacini, Purnima
McQueen, Matthew J.
McDonald, Sarah
Persadie, Richard
Hunter, Barry
Bourgeois, Jacqueline
Jansen, Jan W.
Teo, Koon K.
author_facet Morrison, Katherine M.
Anand, Sonia S.
Yusuf, Salim
Atkinson, Stephanie A.
Schulze, Karleen M.
Rao-Melacini, Purnima
McQueen, Matthew J.
McDonald, Sarah
Persadie, Richard
Hunter, Barry
Bourgeois, Jacqueline
Jansen, Jan W.
Teo, Koon K.
author_sort Morrison, Katherine M.
collection PubMed
description BACKGROUND: The influence of multiple maternal and pregnancy characteristics on offspring cardiometabolic traits at birth is not well understood and was evaluated in this study. METHODS AND FINDINGS: The Family Atherosclerosis Monitoring In earLY life (FAMILY) Study prospectively evaluated 11 cardiometabolic traits in 901 babies born to 857 mothers. The influence of maternal age, health (pre-pregnancy weight, blood pressure, glycemic status, lipids), health behaviors (diet, activity, smoking) and pregnancy characteristics (gestational age at birth, gestational weight gain and placental-fetal ratio) were examined. Greater gestational age influenced multiple newborn cardiometabolic traits including cord blood lipids, glucose and insulin, body fat and blood pressure. In a subset of 442 singleton mother/infant pairs, principal component analysis grouped 11 newborn cardiometabolic traits into 5 components (anthropometry/insulin, 2 lipid components, blood pressure and glycemia), accounting for 74% of the variance of the 11 outcome variables. Determinants of these components, corrected for sex and gestational age, were examined. Baby anthropometry/insulin was independently predicted by higher maternal pre-pregnancy weight (standardized estimate 0.30) and gestational weight gain (0.30; both p<0.0001) and was inversely related to smoking during pregnancy (−0.144; p = 0.01) and maternal polyunsaturated to saturated fat intake (−0.135;p = 0.01). Component 2 (HDL-C/Apo Apolipoprotein1) was inversely associated with maternal age. Component 3 (blood pressure) was not clustered with any other newborn cardiometabolic trait and no associations with maternal pregnancy characteristics were identified. Component 4 (triglycerides) was positively associated with maternal hypertension and triglycerides, and inversely associated with maternal HDL and age. Component 5 (glycemia) was inversely associated with placental/fetal ratio (−0.141; p = 0.005). LDL-C was a bridging variable between the lipid factors and glycemia. CONCLUSIONS: Maternal health, health behaviours and placenta to fetal weight ratio are associated with newborn cardiometabolic traits over and above gestational age. Future investigations are needed to determine if these factors remain important determinants of cardiometabolic health throughout childhood.
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spelling pubmed-35721882013-02-15 Maternal and Pregnancy Related Predictors of Cardiometabolic Traits in Newborns Morrison, Katherine M. Anand, Sonia S. Yusuf, Salim Atkinson, Stephanie A. Schulze, Karleen M. Rao-Melacini, Purnima McQueen, Matthew J. McDonald, Sarah Persadie, Richard Hunter, Barry Bourgeois, Jacqueline Jansen, Jan W. Teo, Koon K. PLoS One Research Article BACKGROUND: The influence of multiple maternal and pregnancy characteristics on offspring cardiometabolic traits at birth is not well understood and was evaluated in this study. METHODS AND FINDINGS: The Family Atherosclerosis Monitoring In earLY life (FAMILY) Study prospectively evaluated 11 cardiometabolic traits in 901 babies born to 857 mothers. The influence of maternal age, health (pre-pregnancy weight, blood pressure, glycemic status, lipids), health behaviors (diet, activity, smoking) and pregnancy characteristics (gestational age at birth, gestational weight gain and placental-fetal ratio) were examined. Greater gestational age influenced multiple newborn cardiometabolic traits including cord blood lipids, glucose and insulin, body fat and blood pressure. In a subset of 442 singleton mother/infant pairs, principal component analysis grouped 11 newborn cardiometabolic traits into 5 components (anthropometry/insulin, 2 lipid components, blood pressure and glycemia), accounting for 74% of the variance of the 11 outcome variables. Determinants of these components, corrected for sex and gestational age, were examined. Baby anthropometry/insulin was independently predicted by higher maternal pre-pregnancy weight (standardized estimate 0.30) and gestational weight gain (0.30; both p<0.0001) and was inversely related to smoking during pregnancy (−0.144; p = 0.01) and maternal polyunsaturated to saturated fat intake (−0.135;p = 0.01). Component 2 (HDL-C/Apo Apolipoprotein1) was inversely associated with maternal age. Component 3 (blood pressure) was not clustered with any other newborn cardiometabolic trait and no associations with maternal pregnancy characteristics were identified. Component 4 (triglycerides) was positively associated with maternal hypertension and triglycerides, and inversely associated with maternal HDL and age. Component 5 (glycemia) was inversely associated with placental/fetal ratio (−0.141; p = 0.005). LDL-C was a bridging variable between the lipid factors and glycemia. CONCLUSIONS: Maternal health, health behaviours and placenta to fetal weight ratio are associated with newborn cardiometabolic traits over and above gestational age. Future investigations are needed to determine if these factors remain important determinants of cardiometabolic health throughout childhood. Public Library of Science 2013-02-13 /pmc/articles/PMC3572188/ /pubmed/23418462 http://dx.doi.org/10.1371/journal.pone.0055815 Text en © 2013 Morrison et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Morrison, Katherine M.
Anand, Sonia S.
Yusuf, Salim
Atkinson, Stephanie A.
Schulze, Karleen M.
Rao-Melacini, Purnima
McQueen, Matthew J.
McDonald, Sarah
Persadie, Richard
Hunter, Barry
Bourgeois, Jacqueline
Jansen, Jan W.
Teo, Koon K.
Maternal and Pregnancy Related Predictors of Cardiometabolic Traits in Newborns
title Maternal and Pregnancy Related Predictors of Cardiometabolic Traits in Newborns
title_full Maternal and Pregnancy Related Predictors of Cardiometabolic Traits in Newborns
title_fullStr Maternal and Pregnancy Related Predictors of Cardiometabolic Traits in Newborns
title_full_unstemmed Maternal and Pregnancy Related Predictors of Cardiometabolic Traits in Newborns
title_short Maternal and Pregnancy Related Predictors of Cardiometabolic Traits in Newborns
title_sort maternal and pregnancy related predictors of cardiometabolic traits in newborns
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572188/
https://www.ncbi.nlm.nih.gov/pubmed/23418462
http://dx.doi.org/10.1371/journal.pone.0055815
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