The KIT Exon 11 Stop Codon Mutation in Gastrointestinal Stromal Tumors: What Is the Clinical Meaning?

BACKGROUND/AIMS: Gastrointestinal stromal tumors (GISTs) strongly express a receptor tyrosine kinase (RTK, c-KIT-CD117) harboring a KIT mutation that causes constitutive receptor activation leading to the development and growth of tumors; 35% of GISTs without KIT mutations have platelet-derived grow...

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Detalles Bibliográficos
Autores principales: Michelucci, Angela, Chiappetta, Caterina, Cacciotti, Jessica, Veccia, Norman, Astri, Elisa, Leopizzi, Martina, Prosperi Porta, Romana, Petrozza, Vincenzo, Della Rocca, Carlo, Bevilacqua, Generoso, Cavazzana, Andrea, Di Cristofano, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Gastroenterology; the Korean Society of Gastrointestinal Endoscopy; the Korean Association for the Study of the Liver; the Korean Society of Neurogastroenterology and Motility; Korean Association for the Study of Intestinal Diseases; Korean College of Helicobacter and Upper Gastrointestinal Research; Korean Pancreatobiliary Association; Korean Society of Gastrointestinal Cancer 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572318/
https://www.ncbi.nlm.nih.gov/pubmed/23423603
http://dx.doi.org/10.5009/gnl.2013.7.1.35

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