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Advance in Photosensitizers and Light Delivery for Photodynamic Therapy

The brief history of photodynamic therapy (PDT) research has been focused on photosensitizers (PSs) and light delivery was introduced recently. The appropriate PSs were developed from the first generation PS Photofrin (QLT) to the second (chlorins or bacteriochlorins derivatives) and third (conjugat...

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Detalles Bibliográficos
Autores principales: Yoon, Il, Li, Jia Zhu, Shim, Young Key
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Gastrointestinal Endoscopy 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572355/
https://www.ncbi.nlm.nih.gov/pubmed/23423543
http://dx.doi.org/10.5946/ce.2013.46.1.7
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author Yoon, Il
Li, Jia Zhu
Shim, Young Key
author_facet Yoon, Il
Li, Jia Zhu
Shim, Young Key
author_sort Yoon, Il
collection PubMed
description The brief history of photodynamic therapy (PDT) research has been focused on photosensitizers (PSs) and light delivery was introduced recently. The appropriate PSs were developed from the first generation PS Photofrin (QLT) to the second (chlorins or bacteriochlorins derivatives) and third (conjugated PSs on carrier) generations PSs to overcome undesired disadvantages, and to increase selective tumor accumulation and excellent targeting. For the synthesis of new chlorin PSs chlorophyll a is isolated from natural plants or algae, and converted to methyl pheophorbide a (MPa) as an important starting material for further synthesis. MPa has various active functional groups easily modified for the preparation of different kinds of PSs, such as methyl pyropheophorbide a, purpurin-18, purpurinimide, and chlorin e6 derivatives. Combination therapy, such as chemotherapy and photothermal therapy with PDT, is shortly described here. Advanced light delivery system is shown to establish successful clinical applications of PDT. Phtodynamic efficiency of the PSs with light delivery was investigated in vitro and/or in vivo.
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spelling pubmed-35723552013-02-19 Advance in Photosensitizers and Light Delivery for Photodynamic Therapy Yoon, Il Li, Jia Zhu Shim, Young Key Clin Endosc Focused Review Series: Photodynamic Therapy The brief history of photodynamic therapy (PDT) research has been focused on photosensitizers (PSs) and light delivery was introduced recently. The appropriate PSs were developed from the first generation PS Photofrin (QLT) to the second (chlorins or bacteriochlorins derivatives) and third (conjugated PSs on carrier) generations PSs to overcome undesired disadvantages, and to increase selective tumor accumulation and excellent targeting. For the synthesis of new chlorin PSs chlorophyll a is isolated from natural plants or algae, and converted to methyl pheophorbide a (MPa) as an important starting material for further synthesis. MPa has various active functional groups easily modified for the preparation of different kinds of PSs, such as methyl pyropheophorbide a, purpurin-18, purpurinimide, and chlorin e6 derivatives. Combination therapy, such as chemotherapy and photothermal therapy with PDT, is shortly described here. Advanced light delivery system is shown to establish successful clinical applications of PDT. Phtodynamic efficiency of the PSs with light delivery was investigated in vitro and/or in vivo. The Korean Society of Gastrointestinal Endoscopy 2013-01 2013-01-31 /pmc/articles/PMC3572355/ /pubmed/23423543 http://dx.doi.org/10.5946/ce.2013.46.1.7 Text en Copyright © 2013 Korean Society of Gastrointestinal Endoscopy http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Focused Review Series: Photodynamic Therapy
Yoon, Il
Li, Jia Zhu
Shim, Young Key
Advance in Photosensitizers and Light Delivery for Photodynamic Therapy
title Advance in Photosensitizers and Light Delivery for Photodynamic Therapy
title_full Advance in Photosensitizers and Light Delivery for Photodynamic Therapy
title_fullStr Advance in Photosensitizers and Light Delivery for Photodynamic Therapy
title_full_unstemmed Advance in Photosensitizers and Light Delivery for Photodynamic Therapy
title_short Advance in Photosensitizers and Light Delivery for Photodynamic Therapy
title_sort advance in photosensitizers and light delivery for photodynamic therapy
topic Focused Review Series: Photodynamic Therapy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572355/
https://www.ncbi.nlm.nih.gov/pubmed/23423543
http://dx.doi.org/10.5946/ce.2013.46.1.7
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