Cargando…

Glycosylation improves α-chymotrypsin stability upon encapsulation in poly(lactic-co-glycolic)acid microspheres

Enhancing protein stability upon encapsulation and release from polymers is a key issue in sustained release applications. In addition, optimum drug dispersion in the polymer particles is critical for achieving release profiles with low unwanted initial “burst” release. Herein, we address both issue...

Descripción completa

Detalles Bibliográficos
Autores principales:	Flores-Fernández, Giselle M., Griebenow, Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572538/ https://www.ncbi.nlm.nih.gov/pubmed/23419866 http://dx.doi.org/10.1016/j.rinphs.2012.08.001

Ejemplares similares

Moisture-induced solid state instabilities in α-chymotrypsin and their reduction through chemical glycosylation
por: Flores-Fernández, Giselle M, et al.
Publicado: (2010)

Safety evaluation of poly(lactic-co-glycolic acid)/poly(lactic-acid) microspheres through intravitreal injection in rabbits
por: Rong, Xianfang, et al.
Publicado: (2014)

The Pharmacokinetics and Pharmacodynamics of Lidocaine-Loaded Biodegradable Poly(lactic-co-glycolic acid) Microspheres
por: Liu, Jianming, et al.
Publicado: (2014)

Using poly(lactic-co-glycolic acid) microspheres to encapsulate plasmid of bone morphogenetic protein 2/polyethylenimine nanoparticles to promote bone formation in vitro and in vivo
por: Qiao, Chunyan, et al.
Publicado: (2013)

Encapsulation of Amikacin into Microparticles Based on Low-Molecular-Weight Poly(lactic acid) and Poly(lactic acid-co-polyethylene glycol)
por: Glinka, Marta, et al.
Publicado: (2021)

A simple and robust method for pre-wetting poly (lactic-co-glycolic) acid microspheres
por: Wright, Bernice, et al.
Publicado: (2015)

Preparation and testing of cefquinome-loaded poly lactic-co-glycolic acid microspheres for lung targeting
por: Qu, Shaoqi, et al.
Publicado: (2017)

Poly(lactic-co-glycolic acid) microsphere production based on quality by design: a review
por: Hua, Yabing, et al.
Publicado: (2021)

Nano-encapsulation and characterization of baricitinib using poly-lactic-glycolic acid co-polymer
por: Ansari, Mohammad Javed, et al.
Publicado: (2019)

Terahertz Spectroscopy: An Investigation of the Structural Dynamics of Freeze-Dried Poly Lactic-co-glycolic Acid Microspheres
por: Shmool, Talia A., et al.
Publicado: (2019)

Surface Modification of Poly(lactic-co-glycolic acid) Microspheres with Enhanced Hydrophilicity and Dispersibility for Arterial Embolization
por: Wang, Jiao, et al.
Publicado: (2019)

Development of Poly Lactic/Glycolic Acid (PLGA) Microspheres for Controlled Release of Rho-Associated Kinase Inhibitor
por: Koda, Sho, et al.
Publicado: (2017)

Experimental Studies and Modeling of the Degradation Process of Poly(Lactic-co-Glycolic Acid) Microspheres for Sustained Protein Release
por: Netti, Paolo Antonio, et al.
Publicado: (2020)

Encapsulation of a Concanavalin A/dendrimer glucose sensing assay within microporated poly (ethylene glycol) microspheres
por: Cummin, Brian M., et al.
Publicado: (2011)

Synergistic Effect of Mesoporous Silica and Hydroxyapatite in Loaded Poly(DL-lactic-co-glycolic acid) Microspheres on the Regeneration of Bone Defects
por: He, Shu, et al.
Publicado: (2016)

Shear Speed-Regulated Properties of Long-Acting Docetaxel Control Release Poly (Lactic-Co-Glycolic Acid) Microspheres
por: Zheng, Yuhao, et al.
Publicado: (2020)

Biodegradable calcium carbonate/mesoporous silica/poly(lactic-glycolic acid) microspheres scaffolds with osteogenesis ability for bone regeneration
por: Xu, Weikang, et al.
Publicado: (2021)

The impact of camptothecin-encapsulated poly(lactic-co-glycolic acid) nanoparticles on the activity of cytochrome P450 in vitro
por: Bao, Hanmei, et al.
Publicado: (2019)

Properties of Poly (Lactic-co-Glycolic Acid) and Progress of Poly (Lactic-co-Glycolic Acid)-Based Biodegradable Materials in Biomedical Research
por: Lu, Yue, et al.
Publicado: (2023)

Osteoinductivity and Antibacterial Properties of Strontium Ranelate-Loaded Poly(Lactic-co-Glycolic Acid) Microspheres With Assembled Silver and Hydroxyapatite Nanoparticles
por: Mao, Zhenyang, et al.
Publicado: (2018)

In Vitro Cell Behavior and Antibiotic Activity under Sustained Release of Doxycycline-Loaded Poly(lactic-co-glycolic acid) Microspheres
por: Pedrini, Flavia, et al.
Publicado: (2022)

Preparation and Characterization of Poly(Lactic Acid)/Poly (ethylene glycol)-Poly(propyl glycol)-Poly(ethylene glycol) Blended Nanofiber Membranes for Fog Collection
por: Aijaz, Muhammad Omer, et al.
Publicado: (2022)

Co-Encapsulation of Methylene Blue and PARP-Inhibitor into Poly(Lactic-Co-Glycolic Acid) Nanoparticles for Enhanced PDT of Cancer
por: Magalhães, Jéssica A., et al.
Publicado: (2021)

Immunogenicity and protective efficacy of an inactivated Newcastle disease virus vaccine encapsulated in poly-(lactic-co-glycolic acid) nanoparticles
por: Ananda Kumar, B.S., et al.
Publicado: (2023)

In vitro stress effect on degradation and drug release behaviors of basic fibroblast growth factor – poly(lactic-co-glycolic-acid) microsphere
por: Xiong, Yan, et al.
Publicado: (2016)

Microsphere-Based Hierarchically Juxtapositioned Biphasic Scaffolds Prepared from Poly(Lactic-co-Glycolic Acid) and Nanohydroxyapatite for Osteochondral Tissue Engineering
por: Shalumon, K. T., et al.
Publicado: (2016)

Butyl stearate prolongs the drug release period of isoperidone-loaded poly (lactic-co-glycolic acid) microspheres: In vitro and in vivo investigation
por: Sun, Fengying, et al.
Publicado: (2019)

Sustained‐release of sclerostin single‐chain antibody fragments using poly(lactic‐co‐glycolic acid) microspheres for osteoporotic fracture repair
por: Li, Ming, et al.
Publicado: (2019)

Long-term sustained release Poly(lactic-co-glycolic acid) microspheres of asenapine maleate with improved bioavailability for chronic neuropsychiatric diseases
por: Zhai, Junqiu, et al.
Publicado: (2020)

Role of Electrospinning Parameters on Poly(Lactic-co-Glycolic Acid) and Poly(Caprolactone-co-Glycolic acid) Membranes
por: Herrero-Herrero, María, et al.
Publicado: (2021)

Liver-targeted cyclosporine A-encapsulated poly (lactic-co-glycolic) acid nanoparticles inhibit hepatitis C virus replication
por: Jyothi, KR, et al.
Publicado: (2015)

Synthesis and Statistical Optimization of Poly (Lactic-Co-Glycolic Acid) Nanoparticles Encapsulating GLP1 Analog Designed for Oral Delivery
por: Ismail, Ruba, et al.
Publicado: (2019)

IKBKB siRNA-Encapsulated Poly (Lactic-co-Glycolic Acid) Nanoparticles Diminish Neuropathic Pain by Inhibiting Microglial Activation
por: Lee, Seounghun, et al.
Publicado: (2021)

Poly Lactic-Co-Glycolic Acid Nano-Carriers for Encapsulation and Controlled Release of Hydrophobic Drug to Enhance the Bioavailability and Antimicrobial Properties
por: Bukhari, Attaullah, et al.
Publicado: (2023)

Hemiacetal stabilization in a chymotrypsin inhibitor complex and the reactivity of the hydroxyl group of the catalytic serine residue of chymotrypsin
por: Cleary, Jennifer A., et al.
Publicado: (2014)

Alginate-Poly(ethylene glycol) Hybrid Microspheres for Primary Cell Microencapsulation
por: Mahou, Redouan, et al.
Publicado: (2014)

Preparing Poly (Lactic-co-Glycolic Acid) (PLGA) Microspheres Containing Lysozyme-Zinc Precipitate Using a Modified Double Emulsion Method
por: Nafissi Varcheh, Nastaran, et al.
Publicado: (2011)

Poly(lactic-co-glycolic) Acid/Nanohydroxyapatite Scaffold Containing Chitosan Microspheres with Adrenomedullin Delivery for Modulation Activity of Osteoblasts and Vascular Endothelial Cells
por: Wang, Lin, et al.
Publicado: (2013)

Gelatin/Nanohyroxyapatite Cryogel Embedded Poly(lactic-co-glycolic Acid)/Nanohydroxyapatite Microsphere Hybrid Scaffolds for Simultaneous Bone Regeneration and Load-Bearing
por: Shalumon, K. T., et al.
Publicado: (2018)

Biphasic Calcium Phosphate (BCP)-Immobilized Porous Poly (d,l-Lactic-co-Glycolic Acid) Microspheres Enhance Osteogenic Activities of Osteoblasts
por: Shim, Kyu-Sik, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_q8dtg0ujctt5csu1p3alfk54u5