Oxygen free radical and antioxidant status in necrotizing soft tissue infection of the lower extremity; a report of two cases with opposite outcomes

Two cases of necrotizing soft tissue infection of the lower extremity were treated concurrently but independently. Multimodal therapy including hip joint disarticulation and hyperbaric oxygen therapy was administered, resulting in opposite outcomes: survival and death. Analysis of the relationships...

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Autores principales: Koakutsu, Tomoaki, Nomura, Ryosuke, Yamanouchi, Satoshi, Kushimoto, Shigeki, Itoi, Eiji, Shinozawa, Yotaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572671/
https://www.ncbi.nlm.nih.gov/pubmed/23163625
http://dx.doi.org/10.3109/03009734.2012.733738
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author Koakutsu, Tomoaki
Nomura, Ryosuke
Yamanouchi, Satoshi
Kushimoto, Shigeki
Itoi, Eiji
Shinozawa, Yotaro
author_facet Koakutsu, Tomoaki
Nomura, Ryosuke
Yamanouchi, Satoshi
Kushimoto, Shigeki
Itoi, Eiji
Shinozawa, Yotaro
author_sort Koakutsu, Tomoaki
collection PubMed
description Two cases of necrotizing soft tissue infection of the lower extremity were treated concurrently but independently. Multimodal therapy including hip joint disarticulation and hyperbaric oxygen therapy was administered, resulting in opposite outcomes: survival and death. Analysis of the relationships between patient outcome and time-course changes in serum diacron-reactive oxygen metabolites (d-ROMs; an index of oxidative stress), antioxidative potential, and cytokines revealed that serum d-ROMs levels decreased with time, but high serum levels of interleukin-10 (anti-inflammatory cytokine) persisted in the patient who died. These findings may reflect an immunosuppressive status unfavorable to infection prevention. Serum d-ROMs may be a prognostic predictor in necrotizing soft tissue infections.
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spelling pubmed-35726712013-03-15 Oxygen free radical and antioxidant status in necrotizing soft tissue infection of the lower extremity; a report of two cases with opposite outcomes Koakutsu, Tomoaki Nomura, Ryosuke Yamanouchi, Satoshi Kushimoto, Shigeki Itoi, Eiji Shinozawa, Yotaro Ups J Med Sci Case Report Two cases of necrotizing soft tissue infection of the lower extremity were treated concurrently but independently. Multimodal therapy including hip joint disarticulation and hyperbaric oxygen therapy was administered, resulting in opposite outcomes: survival and death. Analysis of the relationships between patient outcome and time-course changes in serum diacron-reactive oxygen metabolites (d-ROMs; an index of oxidative stress), antioxidative potential, and cytokines revealed that serum d-ROMs levels decreased with time, but high serum levels of interleukin-10 (anti-inflammatory cytokine) persisted in the patient who died. These findings may reflect an immunosuppressive status unfavorable to infection prevention. Serum d-ROMs may be a prognostic predictor in necrotizing soft tissue infections. Informa Healthcare 2013-03 2013-02-13 /pmc/articles/PMC3572671/ /pubmed/23163625 http://dx.doi.org/10.3109/03009734.2012.733738 Text en © Informa Healthcare http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited.
spellingShingle Case Report
Koakutsu, Tomoaki
Nomura, Ryosuke
Yamanouchi, Satoshi
Kushimoto, Shigeki
Itoi, Eiji
Shinozawa, Yotaro
Oxygen free radical and antioxidant status in necrotizing soft tissue infection of the lower extremity; a report of two cases with opposite outcomes
title Oxygen free radical and antioxidant status in necrotizing soft tissue infection of the lower extremity; a report of two cases with opposite outcomes
title_full Oxygen free radical and antioxidant status in necrotizing soft tissue infection of the lower extremity; a report of two cases with opposite outcomes
title_fullStr Oxygen free radical and antioxidant status in necrotizing soft tissue infection of the lower extremity; a report of two cases with opposite outcomes
title_full_unstemmed Oxygen free radical and antioxidant status in necrotizing soft tissue infection of the lower extremity; a report of two cases with opposite outcomes
title_short Oxygen free radical and antioxidant status in necrotizing soft tissue infection of the lower extremity; a report of two cases with opposite outcomes
title_sort oxygen free radical and antioxidant status in necrotizing soft tissue infection of the lower extremity; a report of two cases with opposite outcomes
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572671/
https://www.ncbi.nlm.nih.gov/pubmed/23163625
http://dx.doi.org/10.3109/03009734.2012.733738
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