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Role of NHE1 in Nociception
Intracellular pH is a fundamental parameter to cell function that requires tight homeostasis. In the absence of any regulation, excessive acidification of the cytosol would have the tendency to produce cellular damage. Mammalian Na(+)/H(+) exchangers (NHEs) are electroneutral Na(+)-dependent protein...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572692/ https://www.ncbi.nlm.nih.gov/pubmed/23431433 http://dx.doi.org/10.1155/2013/217864 |
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author | Torres-López, Jorge Elías Guzmán-Priego, Crystell Guadalupe Rocha-González, Héctor Isaac Granados-Soto, Vinicio |
author_facet | Torres-López, Jorge Elías Guzmán-Priego, Crystell Guadalupe Rocha-González, Héctor Isaac Granados-Soto, Vinicio |
author_sort | Torres-López, Jorge Elías |
collection | PubMed |
description | Intracellular pH is a fundamental parameter to cell function that requires tight homeostasis. In the absence of any regulation, excessive acidification of the cytosol would have the tendency to produce cellular damage. Mammalian Na(+)/H(+) exchangers (NHEs) are electroneutral Na(+)-dependent proteins that exchange extracellular Na(+) for intracellular H(+). To date, there are 9 identified NHE isoforms where NHE1 is the most ubiquitous member, known as the housekeeping exchanger. NHE1 seems to have a protective role in the ischemia-reperfusion injury and other inflammatory diseases. In nociception, NHE1 is found in neurons along nociceptive pathways, and its pharmacological inhibition increases nociceptive behavior in acute pain models at peripheral and central levels. Electrophysiological studies also show that NHE modulates electrical activity of primary nociceptive terminals. However, its role in neuropathic pain still remains controversial. In humans, NHE1 may be responsible for inflammatory bowel diseases since its expression is reduced in Crohn's disease and ulcerative colitis. The purpose of this work is to provide a review of the evidence about participation of NHE1 in the nociceptive processing. |
format | Online Article Text |
id | pubmed-3572692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35726922013-02-21 Role of NHE1 in Nociception Torres-López, Jorge Elías Guzmán-Priego, Crystell Guadalupe Rocha-González, Héctor Isaac Granados-Soto, Vinicio Pain Res Treat Review Article Intracellular pH is a fundamental parameter to cell function that requires tight homeostasis. In the absence of any regulation, excessive acidification of the cytosol would have the tendency to produce cellular damage. Mammalian Na(+)/H(+) exchangers (NHEs) are electroneutral Na(+)-dependent proteins that exchange extracellular Na(+) for intracellular H(+). To date, there are 9 identified NHE isoforms where NHE1 is the most ubiquitous member, known as the housekeeping exchanger. NHE1 seems to have a protective role in the ischemia-reperfusion injury and other inflammatory diseases. In nociception, NHE1 is found in neurons along nociceptive pathways, and its pharmacological inhibition increases nociceptive behavior in acute pain models at peripheral and central levels. Electrophysiological studies also show that NHE modulates electrical activity of primary nociceptive terminals. However, its role in neuropathic pain still remains controversial. In humans, NHE1 may be responsible for inflammatory bowel diseases since its expression is reduced in Crohn's disease and ulcerative colitis. The purpose of this work is to provide a review of the evidence about participation of NHE1 in the nociceptive processing. Hindawi Publishing Corporation 2013 2013-01-30 /pmc/articles/PMC3572692/ /pubmed/23431433 http://dx.doi.org/10.1155/2013/217864 Text en Copyright © 2013 Jorge Elías Torres-López et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Torres-López, Jorge Elías Guzmán-Priego, Crystell Guadalupe Rocha-González, Héctor Isaac Granados-Soto, Vinicio Role of NHE1 in Nociception |
title | Role of NHE1 in Nociception |
title_full | Role of NHE1 in Nociception |
title_fullStr | Role of NHE1 in Nociception |
title_full_unstemmed | Role of NHE1 in Nociception |
title_short | Role of NHE1 in Nociception |
title_sort | role of nhe1 in nociception |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572692/ https://www.ncbi.nlm.nih.gov/pubmed/23431433 http://dx.doi.org/10.1155/2013/217864 |
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