Cargando…

Characterization of Spontaneous and TGF-β-Induced Cell Motility of Primary Human Normal and Neoplastic Mammary Cells In Vitro Using Novel Real-Time Technology

The clinical complications derived from metastatic disease are responsible for the majority of all breast cancer related deaths. Since cell migration and invasion are a prerequisite for metastasis their assessment in patient cancer cells in vitro may have prognostic value for the tumor's metast...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mandel, Katharina, Seidl, Daniel, Rades, Dirk, Lehnert, Hendrik, Gieseler, Frank, Hass, Ralf, Ungefroren, Hendrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572945/ https://www.ncbi.nlm.nih.gov/pubmed/23457587 http://dx.doi.org/10.1371/journal.pone.0056591

Ejemplares similares

Correction: Characterization of Spontaneous and TGF-β-Induced Cell Motility of Primary Human Normal and Neoplastic Mammary Cells In Vitro Using Novel Real-Time Technology
por: Mandel, Katharina, et al.
Publicado: (2013)

The Role of PAR2 in TGF-β1-Induced ERK Activation and Cell Motility
por: Ungefroren, Hendrik, et al.
Publicado: (2017)

Interaction of tumor cells with the microenvironment
por: Ungefroren, Hendrik, et al.
Publicado: (2011)

Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling
por: Ungefroren, Hendrik, et al.
Publicado: (2013)

Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action
por: Bartscht, Tobias, et al.
Publicado: (2015)

Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1
por: Ungefroren, Hendrik, et al.
Publicado: (2011)

RAC1B Suppresses TGF-β1-Dependent Cell Migration in Pancreatic Carcinoma Cells through Inhibition of the TGF-β Type I Receptor ALK5
por: Ungefroren, Hendrik, et al.
Publicado: (2019)

The role of TGF-β and its crosstalk with RAC1/RAC1b signaling in breast and pancreas carcinoma
por: Melzer, Catharina, et al.
Publicado: (2017)

Signaling Crosstalk of TGF-β/ALK5 and PAR2/PAR1: A Complex Regulatory Network Controlling Fibrosis and Cancer
por: Ungefroren, Hendrik, et al.
Publicado: (2018)

RAC1B Regulation of TGFB1 Reveals an Unexpected Role of Autocrine TGFβ1 in the Suppression of Cell Motility
por: Ungefroren, Hendrik, et al.
Publicado: (2020)

Proteinase-Activated Receptor 2 May Drive Cancer Progression by Facilitating TGF-β Signaling
por: Ungefroren, Hendrik, et al.
Publicado: (2017)

Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells
por: Melzer, Catharina, et al.
Publicado: (2017)

RAC1B: A Rho GTPase with Versatile Functions in Malignant Transformation and Tumor Progression
por: Melzer, Catharina, et al.
Publicado: (2019)

Proteinase-Activated Receptor 2 Is a Novel Regulator of TGF-β Signaling in Pancreatic Cancer
por: Witte, David, et al.
Publicado: (2016)

TGF-β-Dependent Growth Arrest and Cell Migration in Benign and Malignant Breast Epithelial Cells Are Antagonistically Controlled by Rac1 and Rac1b
por: Melzer, Catharina, et al.
Publicado: (2017)

Changes in uPA, PAI-1, and TGF-β Production during Breast Cancer Cell Interaction with Human Mesenchymal Stroma/Stem-Like Cells (MSC)
por: Melzer, Catharina, et al.
Publicado: (2019)

Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5
por: Zeeh, Franziska, et al.
Publicado: (2016)

Autocrine TGFβ1 Opposes Exogenous TGFβ1-Induced Cell Migration and Growth Arrest through Sustainment of a Feed-Forward Loop Involving MEK-ERK Signaling
por: Ungefroren, Hendrik, et al.
Publicado: (2021)

Potential Role of MSC/Cancer Cell Fusion and EMT for Breast Cancer Stem Cell Formation
por: Hass, Ralf, et al.
Publicado: (2019)

RAC1B Induces SMAD7 via USP26 to Suppress TGFβ1-Dependent Cell Migration in Mesenchymal-Subtype Carcinoma Cells
por: Ungefroren, Hendrik, et al.
Publicado: (2020)

Negative Control of Cell Migration by Rac1b in Highly Metastatic Pancreatic Cancer Cells Is Mediated by Sequential Induction of Nonactivated Smad3 and Biglycan
por: Otterbein, Hannah, et al.
Publicado: (2019)

Impact of the Tumor Microenvironment on Tumor Heterogeneity and Consequences for Cancer Cell Plasticity and Stemness
por: Hass, Ralf, et al.
Publicado: (2020)

Mesenchymal stem cells as all-round supporters in a normal and neoplastic microenvironment
por: Hass, Ralf, et al.
Publicado: (2012)

The Small GTPase RAC1B: A Potent Negative Regulator of-and Useful Tool to Study-TGFβ Signaling
por: Ungefroren, Hendrik, et al.
Publicado: (2020)

Autocrine TGF-β in Cancer: Review of the Literature and Caveats in Experimental Analysis
por: Ungefroren, Hendrik
Publicado: (2021)

TGF-β Signaling in Cancer: Control by Negative Regulators and Crosstalk with Proinflammatory and Fibrogenic Pathways
por: Ungefroren, Hendrik
Publicado: (2019)

RAC1B Suppresses TGF-β-Dependent Chemokinesis and Growth Inhibition through an Autoregulatory Feed-Forward Loop Involving PAR2 and ALK5
por: Otterbein, Hannah, et al.
Publicado: (2019)

Suppressive Role of ACVR1/ALK2 in Basal and TGFβ1-Induced Cell Migration in Pancreatic Ductal Adenocarcinoma Cells and Identification of a Self-Perpetuating Autoregulatory Loop Involving the Small GTPase RAC1b
por: Ungefroren, Hendrik, et al.
Publicado: (2022)

Negative regulation of TGF-β1-induced MKK6-p38 and MEK-ERK signalling and epithelial-mesenchymal transition by Rac1b
por: Witte, David, et al.
Publicado: (2017)

The Intimate Relationship among EMT, MET and TME: A T(ransdifferentiation) E(nhancing) M(ix) to Be Exploited for Therapeutic Purposes
por: Hass, Ralf, et al.
Publicado: (2020)

Effect of Invasion of Borrelia burgdorferi in Normal and Neoplastic Mammary Epithelial Cells
por: Gaur, Gauri, et al.
Publicado: (2021)

Occluding junctions and cell behavior in primary cultures of normal and neoplastic mammary gland cells
Publicado: (1975)

Quantitation of TGF-β proteins in mouse tissues shows reciprocal changes in TGF-β1 and TGF-β3 in normal vs neoplastic mammary epithelium
por: Flanders, Kathleen C., et al.
Publicado: (2016)

RAC1B: A Guardian of the Epithelial Phenotype and Protector Against Epithelial-Mesenchymal Transition
por: Zinn, Rabea, et al.
Publicado: (2019)

Dual recombinase action in the normal and neoplastic mammary gland epithelium
por: Rädler, Patrick D., et al.
Publicado: (2021)

TGF-β regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells
por: Remšík, Ján, et al.
Publicado: (2020)

Expression of Ly‐6D on the Surface of Normal and Neoplastic Mammary Epithelial Cells of the Mouse
por: Tsukada, Yasukatsu, et al.
Publicado: (2002)

TAp73 Inhibits EMT and Cell Migration in Pancreatic Cancer Cells through Promoting SMAD4 Expression and SMAD4-Dependent Inhibition of ERK Activation
por: Ungefroren, Hendrik, et al.
Publicado: (2023)

Proteinase-activated receptors (PARs) – focus on receptor-receptor-interactions and their physiological and pathophysiological impact
por: Gieseler, Frank, et al.
Publicado: (2013)

Pluripotency Gene Expression and Growth Control in Cultures of Peripheral Blood Monocytes during Their Conversion into Programmable Cells of Monocytic Origin (PCMO): Evidence for a Regulatory Role of Autocrine Activin and TGF-β
por: Ungefroren, Hendrik, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_keo0comquhri8enqlnhcen27se