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Pneumocystis jiroveci pneumonia and colonization in patients with advanced lung cancer

Pneumocystis jiroveci pneumonia (PCP) has long been recognized as a cause of mortality in immuno-compromised populations, including those with advanced lung cancer. Although Pneumocystis colonization has only recently been described due to the development of more sensitive molecular techniques, incl...

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Autores principales: TOGASHI, YOSUKE, MASAGO, KATSUHIRO, ITO, YUTAKA, SAKAMORI, YUICHI, OKUDA, CHIYUKI, FUKUHARA, AKIKO, NAGAI, HIROKI, KIM, YOUNG HAK, MISHIMA, MICHIAKI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572999/
https://www.ncbi.nlm.nih.gov/pubmed/23420670
http://dx.doi.org/10.3892/ol.2012.1052
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author TOGASHI, YOSUKE
MASAGO, KATSUHIRO
ITO, YUTAKA
SAKAMORI, YUICHI
OKUDA, CHIYUKI
FUKUHARA, AKIKO
NAGAI, HIROKI
KIM, YOUNG HAK
MISHIMA, MICHIAKI
author_facet TOGASHI, YOSUKE
MASAGO, KATSUHIRO
ITO, YUTAKA
SAKAMORI, YUICHI
OKUDA, CHIYUKI
FUKUHARA, AKIKO
NAGAI, HIROKI
KIM, YOUNG HAK
MISHIMA, MICHIAKI
author_sort TOGASHI, YOSUKE
collection PubMed
description Pneumocystis jiroveci pneumonia (PCP) has long been recognized as a cause of mortality in immuno-compromised populations, including those with advanced lung cancer. Although Pneumocystis colonization has only recently been described due to the development of more sensitive molecular techniques, including polymerase chain reaction (PCR), it is unknown whether Pneumocystis colonization leads to the development of PCP. In the present study, we aimed to determine the prevalence of Pneumocystis colonization in advanced lung cancer patients. Furthermore, the association between PCP and Pneumocystis colonization was also investigated. Advanced lung cancer patients with no indication of PCP were evaluated to determine the prevalence of Pneumocystis colonization. We analyzed their oral wash (OW) samples and retrospectively evaluated advanced lung cancer patients with PCP by analyzing their sections of formalin-fixed, paraffin-embedded lung tissues obtained following a diagnosis of lung cancer. Pneumocystis colonization was determined by a PCR test for Pneumocystis jiroveci (P. jiroveci). No P. jiroveci was detected by PCR in the OW samples of 47 advanced lung cancer patients with no indication of PCP, or in the lung tissues of four advanced lung cancer patients with PCP. These results indicate that PCP is not associated with Pneumocystis colonization in advanced lung cancer patients, although this study is limited since this was a cross-sectional and retrospective study.
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spelling pubmed-35729992013-02-15 Pneumocystis jiroveci pneumonia and colonization in patients with advanced lung cancer TOGASHI, YOSUKE MASAGO, KATSUHIRO ITO, YUTAKA SAKAMORI, YUICHI OKUDA, CHIYUKI FUKUHARA, AKIKO NAGAI, HIROKI KIM, YOUNG HAK MISHIMA, MICHIAKI Oncol Lett Articles Pneumocystis jiroveci pneumonia (PCP) has long been recognized as a cause of mortality in immuno-compromised populations, including those with advanced lung cancer. Although Pneumocystis colonization has only recently been described due to the development of more sensitive molecular techniques, including polymerase chain reaction (PCR), it is unknown whether Pneumocystis colonization leads to the development of PCP. In the present study, we aimed to determine the prevalence of Pneumocystis colonization in advanced lung cancer patients. Furthermore, the association between PCP and Pneumocystis colonization was also investigated. Advanced lung cancer patients with no indication of PCP were evaluated to determine the prevalence of Pneumocystis colonization. We analyzed their oral wash (OW) samples and retrospectively evaluated advanced lung cancer patients with PCP by analyzing their sections of formalin-fixed, paraffin-embedded lung tissues obtained following a diagnosis of lung cancer. Pneumocystis colonization was determined by a PCR test for Pneumocystis jiroveci (P. jiroveci). No P. jiroveci was detected by PCR in the OW samples of 47 advanced lung cancer patients with no indication of PCP, or in the lung tissues of four advanced lung cancer patients with PCP. These results indicate that PCP is not associated with Pneumocystis colonization in advanced lung cancer patients, although this study is limited since this was a cross-sectional and retrospective study. D.A. Spandidos 2013-02 2012-11-29 /pmc/articles/PMC3572999/ /pubmed/23420670 http://dx.doi.org/10.3892/ol.2012.1052 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
TOGASHI, YOSUKE
MASAGO, KATSUHIRO
ITO, YUTAKA
SAKAMORI, YUICHI
OKUDA, CHIYUKI
FUKUHARA, AKIKO
NAGAI, HIROKI
KIM, YOUNG HAK
MISHIMA, MICHIAKI
Pneumocystis jiroveci pneumonia and colonization in patients with advanced lung cancer
title Pneumocystis jiroveci pneumonia and colonization in patients with advanced lung cancer
title_full Pneumocystis jiroveci pneumonia and colonization in patients with advanced lung cancer
title_fullStr Pneumocystis jiroveci pneumonia and colonization in patients with advanced lung cancer
title_full_unstemmed Pneumocystis jiroveci pneumonia and colonization in patients with advanced lung cancer
title_short Pneumocystis jiroveci pneumonia and colonization in patients with advanced lung cancer
title_sort pneumocystis jiroveci pneumonia and colonization in patients with advanced lung cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572999/
https://www.ncbi.nlm.nih.gov/pubmed/23420670
http://dx.doi.org/10.3892/ol.2012.1052
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