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Inverted Expression Profiles of Sex-Biased Genes in Response to Toxicant Perturbations and Diseases
The influence of sex factor is widely recognized in various diseases, but its molecular basis, particularly how sex-biased genes, those with sexually dimorphic expression, behave in response to toxico-pathological changes is poorly understood. In this study, zebrafish toxicogenomic data and transcri...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573008/ https://www.ncbi.nlm.nih.gov/pubmed/23457601 http://dx.doi.org/10.1371/journal.pone.0056668 |
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author | Ung, Choong Yong Lam, Siew Hong Zhang, Xun Li, Hu Zhang, Louxin Li, Baowen Gong, Zhiyuan |
author_facet | Ung, Choong Yong Lam, Siew Hong Zhang, Xun Li, Hu Zhang, Louxin Li, Baowen Gong, Zhiyuan |
author_sort | Ung, Choong Yong |
collection | PubMed |
description | The influence of sex factor is widely recognized in various diseases, but its molecular basis, particularly how sex-biased genes, those with sexually dimorphic expression, behave in response to toxico-pathological changes is poorly understood. In this study, zebrafish toxicogenomic data and transcriptomic data from human pathological studies were analysed for the responses of male- and female-biased genes. Our analyses revealed obvious inverted expression profiles of sex-biased genes, where affected males tended to up-regulate genes of female-biased expression and down-regulate genes of male-biased expression, and vice versa in affected females, in a broad range of toxico-pathological conditions. Intriguingly, the extent of these inverted profiles correlated well to the susceptibility or severity of a given toxico-pathological state, suggesting that inverted expression profiles of sex-biased genes observed in this study can be used as important indicators to assess biological disorders. |
format | Online Article Text |
id | pubmed-3573008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35730082013-03-01 Inverted Expression Profiles of Sex-Biased Genes in Response to Toxicant Perturbations and Diseases Ung, Choong Yong Lam, Siew Hong Zhang, Xun Li, Hu Zhang, Louxin Li, Baowen Gong, Zhiyuan PLoS One Research Article The influence of sex factor is widely recognized in various diseases, but its molecular basis, particularly how sex-biased genes, those with sexually dimorphic expression, behave in response to toxico-pathological changes is poorly understood. In this study, zebrafish toxicogenomic data and transcriptomic data from human pathological studies were analysed for the responses of male- and female-biased genes. Our analyses revealed obvious inverted expression profiles of sex-biased genes, where affected males tended to up-regulate genes of female-biased expression and down-regulate genes of male-biased expression, and vice versa in affected females, in a broad range of toxico-pathological conditions. Intriguingly, the extent of these inverted profiles correlated well to the susceptibility or severity of a given toxico-pathological state, suggesting that inverted expression profiles of sex-biased genes observed in this study can be used as important indicators to assess biological disorders. Public Library of Science 2013-02-14 /pmc/articles/PMC3573008/ /pubmed/23457601 http://dx.doi.org/10.1371/journal.pone.0056668 Text en © 2013 Ung et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Ung, Choong Yong Lam, Siew Hong Zhang, Xun Li, Hu Zhang, Louxin Li, Baowen Gong, Zhiyuan Inverted Expression Profiles of Sex-Biased Genes in Response to Toxicant Perturbations and Diseases |
title | Inverted Expression Profiles of Sex-Biased Genes in Response to Toxicant Perturbations and Diseases |
title_full | Inverted Expression Profiles of Sex-Biased Genes in Response to Toxicant Perturbations and Diseases |
title_fullStr | Inverted Expression Profiles of Sex-Biased Genes in Response to Toxicant Perturbations and Diseases |
title_full_unstemmed | Inverted Expression Profiles of Sex-Biased Genes in Response to Toxicant Perturbations and Diseases |
title_short | Inverted Expression Profiles of Sex-Biased Genes in Response to Toxicant Perturbations and Diseases |
title_sort | inverted expression profiles of sex-biased genes in response to toxicant perturbations and diseases |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573008/ https://www.ncbi.nlm.nih.gov/pubmed/23457601 http://dx.doi.org/10.1371/journal.pone.0056668 |
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