Cargando…

Reactive Oxygen Species Modulate the Barrier Function of the Human Glomerular Endothelial Glycocalyx

Reactive oxygen species (ROS) play a key role in the pathogenesis of proteinuria in glomerular diseases like diabetic nephropathy. Glomerular endothelial cell (GEnC) glycocalyx covers the luminal aspect of the glomerular capillary wall and makes an important contribution to the glomerular barrier. R...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singh, Anurag, Ramnath, Raina D., Foster, Rebecca R., Wylie, Emma C., Fridén, Vincent, Dasgupta, Ishita, Haraldsson, Borje, Welsh, Gavin I., Mathieson, Peter W., Satchell, Simon C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573029/ https://www.ncbi.nlm.nih.gov/pubmed/23457483 http://dx.doi.org/10.1371/journal.pone.0055852

Ejemplares similares

Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease
por: Ramnath, Raina D., et al.
Publicado: (2020)

Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx
por: Crompton, Michael, et al.
Publicado: (2023)

Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice
por: Qiu, Yan, et al.
Publicado: (2022)

Visualising the endothelial glycocalyx in dogs
por: Lawrence-Mills, Sara J., et al.
Publicado: (2022)

Functional distinctions in cytosolic calcium regulation between cells of the glomerular filtration barrier
por: Foster, Rebecca Rachael, et al.
Publicado: (2010)

Glomerular endothelial cell fenestrations: an integral component of the glomerular filtration barrier
por: Satchell, Simon C., et al.
Publicado: (2009)

The Glomerular Endothelium Restricts Albumin Filtration
por: Ballermann, Barbara J., et al.
Publicado: (2021)

Proteoglycans contribute to the functional integrity of the glomerular endothelial cell surface layer and are regulated in diabetic kidney disease
por: Khramova, Alina, et al.
Publicado: (2021)

Acute laminar shear stress reversibly increases human glomerular endothelial cell permeability via activation of endothelial nitric oxide synthase
por: Bevan, Heather S., et al.
Publicado: (2011)

The unique structural and functional characteristics of glomerular endothelial cell fenestrations and their potential as a therapeutic target in kidney disease
por: Finch, Natalie C., et al.
Publicado: (2023)

Role of Glomerular Proteoglycans in IgA Nephropathy
por: Ebefors, Kerstin, et al.
Publicado: (2011)

An In Vitro Model of the Glomerular Capillary Wall Using Electrospun Collagen Nanofibres in a Bioartificial Composite Basement Membrane
por: Slater, Sadie C., et al.
Publicado: (2011)

Sepsis induces an early impairment of endothelial glycocalyx in glomerular capillaries
por: Vitali, L, et al.
Publicado: (2009)

Glomerular IgG subclasses in idiopathic and malignancy-associated membranous nephropathy
por: Lönnbro-Widgren, Jennie, et al.
Publicado: (2015)

Circulating hyaluronan as a marker of endothelial glycocalyx damage in dogs with myxomatous mitral valve disease and dogs in a hypercoagulable state
por: Lawrence-Mills, Sara J., et al.
Publicado: (2022)

The authors reply
por: Ramnath, Raina D., et al.
Publicado: (2020)

Glomerular endothelial glycocalyx-derived heparan sulfate inhibits glomerular leukocyte influx and attenuates experimental glomerulonephritis
por: Maciej-Hulme, Marissa L., et al.
Publicado: (2023)

The microvascular endothelial glycocalyx: An additional piece of the puzzle in veterinary medicine
por: Lawrence-Mills, Sara J., et al.
Publicado: (2022)

Essential role and therapeutic targeting of the glomerular endothelial glycocalyx in lupus nephritis
por: Kadoya, Hiroyuki, et al.
Publicado: (2020)

Exploring the mechanism of hyperpermeability following glycocalyx degradation: Beyond the glycocalyx as a structural barrier
por: Abe, Kyoko, et al.
Publicado: (2021)

Regional distribution of N-acetyl-D-galactosamine residues in the glycocalyx of glomerular podocytes
Publicado: (1983)

Phenotypic Expression of ADAMTS13 in Glomerular Endothelial Cells
por: Tati, Ramesh, et al.
Publicado: (2011)

Mutations in the heparan sulfate backbone elongating enzymes EXT1 and EXT2 have no major effect on endothelial glycocalyx and the glomerular filtration barrier
por: Khalil, Ramzi, et al.
Publicado: (2022)

Sialic acids regulate microvessel permeability, revealed by novel in vivo studies of endothelial glycocalyx structure and function
por: Betteridge, Kai B., et al.
Publicado: (2017)

What is the mechanism of microalbuminuria in diabetes: a role for the glomerular endothelium?
por: Satchell, S. C., et al.
Publicado: (2008)

The endothelial glycocalyx: An important regulator of the pulmonary vascular barrier
por: Yang, Yimu, et al.
Publicado: (2013)

The Role of Heparin and Glycocalyx in Blood–Brain Barrier Dysfunction
por: Yang, Rui, et al.
Publicado: (2021)

Reactive Oxygen Species in the Tumor Microenvironment: An Overview
por: Weinberg, Frank, et al.
Publicado: (2019)

Salt overload damages the glycocalyx sodium barrier of vascular endothelium
por: Oberleithner, Hans, et al.
Publicado: (2011)

The Structure and Function of the Glycocalyx and Its Connection With Blood-Brain Barrier
por: Jin, Jing, et al.
Publicado: (2021)

Endothelial glycocalyx as an important factor in composition of blood‐brain barrier
por: Zhao, Fangfang, et al.
Publicado: (2020)

The glycocalyx as a permeability barrier: basic science and clinical evidence
por: Dull, Randal O., et al.
Publicado: (2022)

Effects of controlled ovarian stimulation on vascular barrier and endothelial glycocalyx: a pilot study
por: Hulde, Nikolai, et al.
Publicado: (2021)

The Glomerular Filtration Barrier: Components and Crosstalk
por: Menon, Madhav C., et al.
Publicado: (2012)

Minimal Change Disease Is Associated With Endothelial Glycocalyx Degradation and Endothelial Activation
por: Bauer, Colin, et al.
Publicado: (2021)

Effect of acute hypobaric hypoxia on the endothelial glycocalyx and digital reactive hyperemia in humans
por: Johansson, Pär I., et al.
Publicado: (2014)

Hydrogen Sulfide Is a Novel Protector of the Retinal Glycocalyx and Endothelial Permeability Barrier
por: Allen, Claire L., et al.
Publicado: (2021)

The molecular and functional phenotype of glomerular podocytes reveals key features of contractile smooth muscle cells
por: Saleem, Moin A., et al.
Publicado: (2008)

The glycocalyx: Pathobiology and repair
por: Richter, Jillian R., et al.
Publicado: (2023)

A novel assay provides sensitive measurement of physiologically relevant changes in albumin permeability in isolated human and rodent glomeruli
por: Desideri, Sara, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_jimr8bkc0fuv1g292hsuav2jfp