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Pancreatic cyst fluid analysis for differential diagnosis between benign and malignant lesions
The majority of pancreatic cysts are detected incidentally when abdominal imaging is performed during unrelated procedures. The aim of the present study was to assess the diagnostic utility and clinical value of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9) and amylase analysis...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573134/ https://www.ncbi.nlm.nih.gov/pubmed/23420052 http://dx.doi.org/10.3892/ol.2012.1071 |
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author | TALAR-WOJNAROWSKA, RENATA PAZUREK, MAREK DURKO, LUKASZ DEGOWSKA, MALGORZATA RYDZEWSKA, GRAZYNA SMIGIELSKI, JACEK JANIAK, ADAM OLAKOWSKI, MAREK LAMPE, PAWEŁ GRZELAK, PIOTR STEFANCZYK, LUDOMIR MALECKA-PANAS, EWA |
author_facet | TALAR-WOJNAROWSKA, RENATA PAZUREK, MAREK DURKO, LUKASZ DEGOWSKA, MALGORZATA RYDZEWSKA, GRAZYNA SMIGIELSKI, JACEK JANIAK, ADAM OLAKOWSKI, MAREK LAMPE, PAWEŁ GRZELAK, PIOTR STEFANCZYK, LUDOMIR MALECKA-PANAS, EWA |
author_sort | TALAR-WOJNAROWSKA, RENATA |
collection | PubMed |
description | The majority of pancreatic cysts are detected incidentally when abdominal imaging is performed during unrelated procedures. The aim of the present study was to assess the diagnostic utility and clinical value of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9) and amylase analysis in pancreatic cyst fluid. The study included 52 patients with pancreatic cystic lesions, who underwent fine-needle aspiration biopsy to collect cystic fluid for cytological and biochemical analysis. Cysts were classified as benign (simple cysts, pseudocysts and serous cystadenomas) in 36 patients or premalignant/malignant (mucinous cyst-adenomas, intraductal papillary mucinous neoplasm and cystadenocarcinomas) in 16 patients. CEA and CA 19-9 were elevated in patients with malignant cysts (238±12.5 ng/ml and 222±31.5 U/ml, respectively) compared with benign lesions (34.5±3.7 ng/ml and 18.5±1.9 U/ml, respectively; P<0.001). Based on these results, the sensitivity and specificity of CEA were 91.8 and 63.9% and of CA 19-9 were 81.3 and 69.4%, respectively. Mean amylase levels in benign lesions (27825.7±91.9 U/l) were higher compared with malignant pancreatic cysts (8359.2±32.7 U/l; P<0.05). Cyst fluid analysis may prove a safe and useful adjunct for the differential diagnosis of pancreatic cystic lesions. In the present study, promising results for CEA and CA 19-9 have been demonstrated, however, the clinical value of these molecules must be confirmed. |
format | Online Article Text |
id | pubmed-3573134 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-35731342013-02-15 Pancreatic cyst fluid analysis for differential diagnosis between benign and malignant lesions TALAR-WOJNAROWSKA, RENATA PAZUREK, MAREK DURKO, LUKASZ DEGOWSKA, MALGORZATA RYDZEWSKA, GRAZYNA SMIGIELSKI, JACEK JANIAK, ADAM OLAKOWSKI, MAREK LAMPE, PAWEŁ GRZELAK, PIOTR STEFANCZYK, LUDOMIR MALECKA-PANAS, EWA Oncol Lett Articles The majority of pancreatic cysts are detected incidentally when abdominal imaging is performed during unrelated procedures. The aim of the present study was to assess the diagnostic utility and clinical value of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9) and amylase analysis in pancreatic cyst fluid. The study included 52 patients with pancreatic cystic lesions, who underwent fine-needle aspiration biopsy to collect cystic fluid for cytological and biochemical analysis. Cysts were classified as benign (simple cysts, pseudocysts and serous cystadenomas) in 36 patients or premalignant/malignant (mucinous cyst-adenomas, intraductal papillary mucinous neoplasm and cystadenocarcinomas) in 16 patients. CEA and CA 19-9 were elevated in patients with malignant cysts (238±12.5 ng/ml and 222±31.5 U/ml, respectively) compared with benign lesions (34.5±3.7 ng/ml and 18.5±1.9 U/ml, respectively; P<0.001). Based on these results, the sensitivity and specificity of CEA were 91.8 and 63.9% and of CA 19-9 were 81.3 and 69.4%, respectively. Mean amylase levels in benign lesions (27825.7±91.9 U/l) were higher compared with malignant pancreatic cysts (8359.2±32.7 U/l; P<0.05). Cyst fluid analysis may prove a safe and useful adjunct for the differential diagnosis of pancreatic cystic lesions. In the present study, promising results for CEA and CA 19-9 have been demonstrated, however, the clinical value of these molecules must be confirmed. D.A. Spandidos 2013-02 2012-12-12 /pmc/articles/PMC3573134/ /pubmed/23420052 http://dx.doi.org/10.3892/ol.2012.1071 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles TALAR-WOJNAROWSKA, RENATA PAZUREK, MAREK DURKO, LUKASZ DEGOWSKA, MALGORZATA RYDZEWSKA, GRAZYNA SMIGIELSKI, JACEK JANIAK, ADAM OLAKOWSKI, MAREK LAMPE, PAWEŁ GRZELAK, PIOTR STEFANCZYK, LUDOMIR MALECKA-PANAS, EWA Pancreatic cyst fluid analysis for differential diagnosis between benign and malignant lesions |
title | Pancreatic cyst fluid analysis for differential diagnosis between benign and malignant lesions |
title_full | Pancreatic cyst fluid analysis for differential diagnosis between benign and malignant lesions |
title_fullStr | Pancreatic cyst fluid analysis for differential diagnosis between benign and malignant lesions |
title_full_unstemmed | Pancreatic cyst fluid analysis for differential diagnosis between benign and malignant lesions |
title_short | Pancreatic cyst fluid analysis for differential diagnosis between benign and malignant lesions |
title_sort | pancreatic cyst fluid analysis for differential diagnosis between benign and malignant lesions |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573134/ https://www.ncbi.nlm.nih.gov/pubmed/23420052 http://dx.doi.org/10.3892/ol.2012.1071 |
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