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Effects of reboxetine and citalopram on appraisal of infant facial expressions and attentional biases

Difficulties in mother–child interaction are commonly observed in the context of postnatal depression. These difficulties may result in part from the negative cognitive bias present in depression, which may in turn lead to biased negative perceptions of the infant: in particular, these biases encomp...

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Autores principales: Stein, Alan, Murphy, Susannah, Arteche, Adriane, Lehtonen, Annukka, Harvey, Allison, Craske, Michelle G, Harmer, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573684/
https://www.ncbi.nlm.nih.gov/pubmed/21948858
http://dx.doi.org/10.1177/0269881111421970
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author Stein, Alan
Murphy, Susannah
Arteche, Adriane
Lehtonen, Annukka
Harvey, Allison
Craske, Michelle G
Harmer, Catherine
author_facet Stein, Alan
Murphy, Susannah
Arteche, Adriane
Lehtonen, Annukka
Harvey, Allison
Craske, Michelle G
Harmer, Catherine
author_sort Stein, Alan
collection PubMed
description Difficulties in mother–child interaction are commonly observed in the context of postnatal depression. These difficulties may result in part from the negative cognitive bias present in depression, which may in turn lead to biased negative perceptions of the infant: in particular, these biases encompass the negative appraisal of facial expressions. Given the important role of early mother–child interactions in child development it is vital to investigate potential interventions that might be beneficial in ameliorating the negative cognitive bias. This study aimed to examine the effects of two different antidepressants (reboxetine and citalopram) on the appraisal of infant facial expressions of emotion using a faces rating task, and on attention to infant emotion using an attentional probe. Thirty-nine volunteers were randomly assigned to a double-blind 7-day intervention with either placebo, citalopram or reboxetine. There were significant positive effects on the appraisal of facial expressions; participants assigned to the placebo group rated positive faces less positively than those either in the citalopram or in the reboxetine groups. However, there was no evidence that these drugs had an effect on attentional vigilance. If antidepressants are able to help a mother to perceive her infant’s facial expressions as more positive, this may lead to more positive interactions, thereby potentially mitigating the negative effects of depression on infant development. These findings should be treated with caution until replicated in larger and clinical samples.
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spelling pubmed-35736842013-02-22 Effects of reboxetine and citalopram on appraisal of infant facial expressions and attentional biases Stein, Alan Murphy, Susannah Arteche, Adriane Lehtonen, Annukka Harvey, Allison Craske, Michelle G Harmer, Catherine J Psychopharmacol Original Papers Difficulties in mother–child interaction are commonly observed in the context of postnatal depression. These difficulties may result in part from the negative cognitive bias present in depression, which may in turn lead to biased negative perceptions of the infant: in particular, these biases encompass the negative appraisal of facial expressions. Given the important role of early mother–child interactions in child development it is vital to investigate potential interventions that might be beneficial in ameliorating the negative cognitive bias. This study aimed to examine the effects of two different antidepressants (reboxetine and citalopram) on the appraisal of infant facial expressions of emotion using a faces rating task, and on attention to infant emotion using an attentional probe. Thirty-nine volunteers were randomly assigned to a double-blind 7-day intervention with either placebo, citalopram or reboxetine. There were significant positive effects on the appraisal of facial expressions; participants assigned to the placebo group rated positive faces less positively than those either in the citalopram or in the reboxetine groups. However, there was no evidence that these drugs had an effect on attentional vigilance. If antidepressants are able to help a mother to perceive her infant’s facial expressions as more positive, this may lead to more positive interactions, thereby potentially mitigating the negative effects of depression on infant development. These findings should be treated with caution until replicated in larger and clinical samples. SAGE Publications 2012-05 /pmc/articles/PMC3573684/ /pubmed/21948858 http://dx.doi.org/10.1177/0269881111421970 Text en © The Author(s) 2012 http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Papers
Stein, Alan
Murphy, Susannah
Arteche, Adriane
Lehtonen, Annukka
Harvey, Allison
Craske, Michelle G
Harmer, Catherine
Effects of reboxetine and citalopram on appraisal of infant facial expressions and attentional biases
title Effects of reboxetine and citalopram on appraisal of infant facial expressions and attentional biases
title_full Effects of reboxetine and citalopram on appraisal of infant facial expressions and attentional biases
title_fullStr Effects of reboxetine and citalopram on appraisal of infant facial expressions and attentional biases
title_full_unstemmed Effects of reboxetine and citalopram on appraisal of infant facial expressions and attentional biases
title_short Effects of reboxetine and citalopram on appraisal of infant facial expressions and attentional biases
title_sort effects of reboxetine and citalopram on appraisal of infant facial expressions and attentional biases
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573684/
https://www.ncbi.nlm.nih.gov/pubmed/21948858
http://dx.doi.org/10.1177/0269881111421970
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