Simple and rapid determination of myristicin in human serum

Myristicin (5-allyl-1-methoxy-2,3-methylenodioxybenzene) is the main component of nutmeg (Myristica fragrans Houtt.) essential oil. The increasing use of myristicin as a cheap hallucinogenic intoxicant, frequently causing fatal cases of myristicin poisoning, requires new methods for determination of...

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Detalles Bibliográficos
Autores principales: Dawidowicz, Andrzej L., Dybowski, Michal P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2012
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573713/
https://www.ncbi.nlm.nih.gov/pubmed/23440626
http://dx.doi.org/10.1007/s11419-012-0151-8
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author Dawidowicz, Andrzej L.
Dybowski, Michal P.
author_facet Dawidowicz, Andrzej L.
Dybowski, Michal P.
author_sort Dawidowicz, Andrzej L.
collection PubMed
description Myristicin (5-allyl-1-methoxy-2,3-methylenodioxybenzene) is the main component of nutmeg (Myristica fragrans Houtt.) essential oil. The increasing use of myristicin as a cheap hallucinogenic intoxicant, frequently causing fatal cases of myristicin poisoning, requires new methods for determination of this compound in blood. This report describes the rapid, simple, and useful procedure for myristicin analysis in human serum, involving myristicin–protein complex degradation before chromatographic analysis. The developed method is characterized by a high recovery (above 99 %), a low detection limit (6.0 ng/g) and good repeatability (average RDS of 2.01 %).
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spelling pubmed-35737132013-02-21 Simple and rapid determination of myristicin in human serum Dawidowicz, Andrzej L. Dybowski, Michal P. Forensic Toxicol Short Communication Myristicin (5-allyl-1-methoxy-2,3-methylenodioxybenzene) is the main component of nutmeg (Myristica fragrans Houtt.) essential oil. The increasing use of myristicin as a cheap hallucinogenic intoxicant, frequently causing fatal cases of myristicin poisoning, requires new methods for determination of this compound in blood. This report describes the rapid, simple, and useful procedure for myristicin analysis in human serum, involving myristicin–protein complex degradation before chromatographic analysis. The developed method is characterized by a high recovery (above 99 %), a low detection limit (6.0 ng/g) and good repeatability (average RDS of 2.01 %). Springer Japan 2012-08-15 2013 /pmc/articles/PMC3573713/ /pubmed/23440626 http://dx.doi.org/10.1007/s11419-012-0151-8 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Short Communication
Dawidowicz, Andrzej L.
Dybowski, Michal P.
Simple and rapid determination of myristicin in human serum
title Simple and rapid determination of myristicin in human serum
title_full Simple and rapid determination of myristicin in human serum
title_fullStr Simple and rapid determination of myristicin in human serum
title_full_unstemmed Simple and rapid determination of myristicin in human serum
title_short Simple and rapid determination of myristicin in human serum
title_sort simple and rapid determination of myristicin in human serum
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573713/
https://www.ncbi.nlm.nih.gov/pubmed/23440626
http://dx.doi.org/10.1007/s11419-012-0151-8
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