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Reconciling the Roles of Kinetic and Thermodynamic Factors in Membrane–Protein Insertion

[Image: see text] For the vast majority of membrane proteins, insertion into a membrane is not direct, but rather is catalyzed by a protein-conducting channel, the translocon. This channel provides a lateral exit into the bilayer while simultaneously offering a pathway into the aqueous lumen. The de...

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Detalles Bibliográficos
Autores principales: Gumbart, James C., Teo, Ivan, Roux, Benoît, Schulten, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573731/
https://www.ncbi.nlm.nih.gov/pubmed/23298280
http://dx.doi.org/10.1021/ja310777k