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An Unusual Presentation of Zollinger-Ellison Syndrome
Zollinger-Ellison syndrome is an often progressive, persistent and frequently life-threatening disease, described for the first time as characterized by ulceration of the upper jejunum, hypersecretion of gastric acid and non-beta islet cell tumors of the pancreas; this syndrome is due to the hyperse...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573777/ https://www.ncbi.nlm.nih.gov/pubmed/23466991 http://dx.doi.org/10.1159/000342355 |
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author | Sinagra, Emanuele Perricone, Giovanni Linea, Cristina Montalbano, Luigi Plano, Stefania Simonetti, Rosa Giovanna Orlando, Ambrogio Romano, Claudia Amvrosiadis, Georgios Messina, Marco Scalisi, Andrea Rizzuto, Maria Rosa Rizzo, Aroldo Gabriele Cottone, Mario |
author_facet | Sinagra, Emanuele Perricone, Giovanni Linea, Cristina Montalbano, Luigi Plano, Stefania Simonetti, Rosa Giovanna Orlando, Ambrogio Romano, Claudia Amvrosiadis, Georgios Messina, Marco Scalisi, Andrea Rizzuto, Maria Rosa Rizzo, Aroldo Gabriele Cottone, Mario |
author_sort | Sinagra, Emanuele |
collection | PubMed |
description | Zollinger-Ellison syndrome is an often progressive, persistent and frequently life-threatening disease, described for the first time as characterized by ulceration of the upper jejunum, hypersecretion of gastric acid and non-beta islet cell tumors of the pancreas; this syndrome is due to the hypersecretion of gastrin. We report a case of Zollinger-Ellison syndrome presenting as severe esophagitis evolving in stenosis, which demonstrates how a delayed diagnosis may induce risk of disease spreading. In this setting new diagnostic approaches, such as somatostatin receptor scanning and positron emission tomography with 68 Ga-labeled octreotide, could be particularly useful, as well as further new therapeutic options, such as molecular targeted treatments and peptide receptor radionuclide therapy, though surgery is currently the only form of curative treatment, and the role of the therapeutic options mentioned needs to be clarified by forthcoming studies. |
format | Online Article Text |
id | pubmed-3573777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-35737772013-03-05 An Unusual Presentation of Zollinger-Ellison Syndrome Sinagra, Emanuele Perricone, Giovanni Linea, Cristina Montalbano, Luigi Plano, Stefania Simonetti, Rosa Giovanna Orlando, Ambrogio Romano, Claudia Amvrosiadis, Georgios Messina, Marco Scalisi, Andrea Rizzuto, Maria Rosa Rizzo, Aroldo Gabriele Cottone, Mario Case Rep Gastroenterol Published online: January, 2013 Zollinger-Ellison syndrome is an often progressive, persistent and frequently life-threatening disease, described for the first time as characterized by ulceration of the upper jejunum, hypersecretion of gastric acid and non-beta islet cell tumors of the pancreas; this syndrome is due to the hypersecretion of gastrin. We report a case of Zollinger-Ellison syndrome presenting as severe esophagitis evolving in stenosis, which demonstrates how a delayed diagnosis may induce risk of disease spreading. In this setting new diagnostic approaches, such as somatostatin receptor scanning and positron emission tomography with 68 Ga-labeled octreotide, could be particularly useful, as well as further new therapeutic options, such as molecular targeted treatments and peptide receptor radionuclide therapy, though surgery is currently the only form of curative treatment, and the role of the therapeutic options mentioned needs to be clarified by forthcoming studies. S. Karger AG 2013-01-03 /pmc/articles/PMC3573777/ /pubmed/23466991 http://dx.doi.org/10.1159/000342355 Text en Copyright © 2013 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published online: January, 2013 Sinagra, Emanuele Perricone, Giovanni Linea, Cristina Montalbano, Luigi Plano, Stefania Simonetti, Rosa Giovanna Orlando, Ambrogio Romano, Claudia Amvrosiadis, Georgios Messina, Marco Scalisi, Andrea Rizzuto, Maria Rosa Rizzo, Aroldo Gabriele Cottone, Mario An Unusual Presentation of Zollinger-Ellison Syndrome |
title | An Unusual Presentation of Zollinger-Ellison Syndrome |
title_full | An Unusual Presentation of Zollinger-Ellison Syndrome |
title_fullStr | An Unusual Presentation of Zollinger-Ellison Syndrome |
title_full_unstemmed | An Unusual Presentation of Zollinger-Ellison Syndrome |
title_short | An Unusual Presentation of Zollinger-Ellison Syndrome |
title_sort | unusual presentation of zollinger-ellison syndrome |
topic | Published online: January, 2013 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573777/ https://www.ncbi.nlm.nih.gov/pubmed/23466991 http://dx.doi.org/10.1159/000342355 |
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