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An Unusual Presentation of Zollinger-Ellison Syndrome

Zollinger-Ellison syndrome is an often progressive, persistent and frequently life-threatening disease, described for the first time as characterized by ulceration of the upper jejunum, hypersecretion of gastric acid and non-beta islet cell tumors of the pancreas; this syndrome is due to the hyperse...

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Autores principales: Sinagra, Emanuele, Perricone, Giovanni, Linea, Cristina, Montalbano, Luigi, Plano, Stefania, Simonetti, Rosa Giovanna, Orlando, Ambrogio, Romano, Claudia, Amvrosiadis, Georgios, Messina, Marco, Scalisi, Andrea, Rizzuto, Maria Rosa, Rizzo, Aroldo Gabriele, Cottone, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573777/
https://www.ncbi.nlm.nih.gov/pubmed/23466991
http://dx.doi.org/10.1159/000342355
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author Sinagra, Emanuele
Perricone, Giovanni
Linea, Cristina
Montalbano, Luigi
Plano, Stefania
Simonetti, Rosa Giovanna
Orlando, Ambrogio
Romano, Claudia
Amvrosiadis, Georgios
Messina, Marco
Scalisi, Andrea
Rizzuto, Maria Rosa
Rizzo, Aroldo Gabriele
Cottone, Mario
author_facet Sinagra, Emanuele
Perricone, Giovanni
Linea, Cristina
Montalbano, Luigi
Plano, Stefania
Simonetti, Rosa Giovanna
Orlando, Ambrogio
Romano, Claudia
Amvrosiadis, Georgios
Messina, Marco
Scalisi, Andrea
Rizzuto, Maria Rosa
Rizzo, Aroldo Gabriele
Cottone, Mario
author_sort Sinagra, Emanuele
collection PubMed
description Zollinger-Ellison syndrome is an often progressive, persistent and frequently life-threatening disease, described for the first time as characterized by ulceration of the upper jejunum, hypersecretion of gastric acid and non-beta islet cell tumors of the pancreas; this syndrome is due to the hypersecretion of gastrin. We report a case of Zollinger-Ellison syndrome presenting as severe esophagitis evolving in stenosis, which demonstrates how a delayed diagnosis may induce risk of disease spreading. In this setting new diagnostic approaches, such as somatostatin receptor scanning and positron emission tomography with 68 Ga-labeled octreotide, could be particularly useful, as well as further new therapeutic options, such as molecular targeted treatments and peptide receptor radionuclide therapy, though surgery is currently the only form of curative treatment, and the role of the therapeutic options mentioned needs to be clarified by forthcoming studies.
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spelling pubmed-35737772013-03-05 An Unusual Presentation of Zollinger-Ellison Syndrome Sinagra, Emanuele Perricone, Giovanni Linea, Cristina Montalbano, Luigi Plano, Stefania Simonetti, Rosa Giovanna Orlando, Ambrogio Romano, Claudia Amvrosiadis, Georgios Messina, Marco Scalisi, Andrea Rizzuto, Maria Rosa Rizzo, Aroldo Gabriele Cottone, Mario Case Rep Gastroenterol Published online: January, 2013 Zollinger-Ellison syndrome is an often progressive, persistent and frequently life-threatening disease, described for the first time as characterized by ulceration of the upper jejunum, hypersecretion of gastric acid and non-beta islet cell tumors of the pancreas; this syndrome is due to the hypersecretion of gastrin. We report a case of Zollinger-Ellison syndrome presenting as severe esophagitis evolving in stenosis, which demonstrates how a delayed diagnosis may induce risk of disease spreading. In this setting new diagnostic approaches, such as somatostatin receptor scanning and positron emission tomography with 68 Ga-labeled octreotide, could be particularly useful, as well as further new therapeutic options, such as molecular targeted treatments and peptide receptor radionuclide therapy, though surgery is currently the only form of curative treatment, and the role of the therapeutic options mentioned needs to be clarified by forthcoming studies. S. Karger AG 2013-01-03 /pmc/articles/PMC3573777/ /pubmed/23466991 http://dx.doi.org/10.1159/000342355 Text en Copyright © 2013 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: January, 2013
Sinagra, Emanuele
Perricone, Giovanni
Linea, Cristina
Montalbano, Luigi
Plano, Stefania
Simonetti, Rosa Giovanna
Orlando, Ambrogio
Romano, Claudia
Amvrosiadis, Georgios
Messina, Marco
Scalisi, Andrea
Rizzuto, Maria Rosa
Rizzo, Aroldo Gabriele
Cottone, Mario
An Unusual Presentation of Zollinger-Ellison Syndrome
title An Unusual Presentation of Zollinger-Ellison Syndrome
title_full An Unusual Presentation of Zollinger-Ellison Syndrome
title_fullStr An Unusual Presentation of Zollinger-Ellison Syndrome
title_full_unstemmed An Unusual Presentation of Zollinger-Ellison Syndrome
title_short An Unusual Presentation of Zollinger-Ellison Syndrome
title_sort unusual presentation of zollinger-ellison syndrome
topic Published online: January, 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573777/
https://www.ncbi.nlm.nih.gov/pubmed/23466991
http://dx.doi.org/10.1159/000342355
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