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p90 Ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists

ERK1/2 (extracellular-signal-regulated kinase 1/2) and their substrates RSKs (p90 ribosomal S6 kinases) phosphorylate different transcription factors, contributing differentially to transcriptomic profiles. In cardiomyocytes ERK1/2 are required for >70% of the transcriptomic response to endotheli...

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Detalles Bibliográficos
Autores principales:	Amirak, Emre, Fuller, Stephen J., Sugden, Peter H., Clerk, Angela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573779/ https://www.ncbi.nlm.nih.gov/pubmed/23215897 http://dx.doi.org/10.1042/BJ20121371

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