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Drug-Induced Liver Injury Associated with Noni (Morinda citrifolia) Juice and Phenobarbital

Noni (Morinda citrifolia) juice is a popular herbal dietary supplement globally used for preventive or therapeutic purposes in a variety of ailments, claiming to exhibit hepatoprotective properties as well. Herein we present the case of a 38-year-old woman who developed acute liver injury associated...

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Autores principales: Mrzljak, Anna, Kosuta, Iva, Skrtic, Anita, Kanizaj, Tajana Filipec, Vrhovac, Radovan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573787/
https://www.ncbi.nlm.nih.gov/pubmed/23467452
http://dx.doi.org/10.1159/000343651
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author Mrzljak, Anna
Kosuta, Iva
Skrtic, Anita
Kanizaj, Tajana Filipec
Vrhovac, Radovan
author_facet Mrzljak, Anna
Kosuta, Iva
Skrtic, Anita
Kanizaj, Tajana Filipec
Vrhovac, Radovan
author_sort Mrzljak, Anna
collection PubMed
description Noni (Morinda citrifolia) juice is a popular herbal dietary supplement globally used for preventive or therapeutic purposes in a variety of ailments, claiming to exhibit hepatoprotective properties as well. Herein we present the case of a 38-year-old woman who developed acute liver injury associated with noni juice consumption on a long-term (9 months) anticonvulsant therapy. Clinical presentation and liver biopsy were consistent with severe, predominantly hepatocellular type of injury. Both agents were stopped and corticosteroids were initiated. Five months later the patient had fully recovered. Although in the literature the hepatotoxicity of noni juice remains speculative, sporadic but emerging cases of noni juice-associated liver injury address the need to clarify and investigate potential harmful effects associated with this supplement.
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spelling pubmed-35737872013-03-05 Drug-Induced Liver Injury Associated with Noni (Morinda citrifolia) Juice and Phenobarbital Mrzljak, Anna Kosuta, Iva Skrtic, Anita Kanizaj, Tajana Filipec Vrhovac, Radovan Case Rep Gastroenterol Published online: January, 2013 Noni (Morinda citrifolia) juice is a popular herbal dietary supplement globally used for preventive or therapeutic purposes in a variety of ailments, claiming to exhibit hepatoprotective properties as well. Herein we present the case of a 38-year-old woman who developed acute liver injury associated with noni juice consumption on a long-term (9 months) anticonvulsant therapy. Clinical presentation and liver biopsy were consistent with severe, predominantly hepatocellular type of injury. Both agents were stopped and corticosteroids were initiated. Five months later the patient had fully recovered. Although in the literature the hepatotoxicity of noni juice remains speculative, sporadic but emerging cases of noni juice-associated liver injury address the need to clarify and investigate potential harmful effects associated with this supplement. S. Karger AG 2013-01-10 /pmc/articles/PMC3573787/ /pubmed/23467452 http://dx.doi.org/10.1159/000343651 Text en Copyright © 2013 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: January, 2013
Mrzljak, Anna
Kosuta, Iva
Skrtic, Anita
Kanizaj, Tajana Filipec
Vrhovac, Radovan
Drug-Induced Liver Injury Associated with Noni (Morinda citrifolia) Juice and Phenobarbital
title Drug-Induced Liver Injury Associated with Noni (Morinda citrifolia) Juice and Phenobarbital
title_full Drug-Induced Liver Injury Associated with Noni (Morinda citrifolia) Juice and Phenobarbital
title_fullStr Drug-Induced Liver Injury Associated with Noni (Morinda citrifolia) Juice and Phenobarbital
title_full_unstemmed Drug-Induced Liver Injury Associated with Noni (Morinda citrifolia) Juice and Phenobarbital
title_short Drug-Induced Liver Injury Associated with Noni (Morinda citrifolia) Juice and Phenobarbital
title_sort drug-induced liver injury associated with noni (morinda citrifolia) juice and phenobarbital
topic Published online: January, 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573787/
https://www.ncbi.nlm.nih.gov/pubmed/23467452
http://dx.doi.org/10.1159/000343651
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