The influence of selective vitamin D receptor activator paricalcitol on cardiovascular system and cardiorenal protection

The ubiquitous distribution of vitamin D receptors in the human body is responsible for the pleiotropic effects of vitamin D-receptor activation. We discuss the possible beneficial effects of a selective activator of vitamin D receptor, paricalcitol, on the cardiovascular system in chronic heart fai...

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Detalles Bibliográficos
Autores principales: Duplancic, Darko, Cesarik, Marijan, Poljak, Nikola Kolja, Radman, Maja, Kovacic, Vedran, Radic, Josipa, Rogosic, Veljko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573827/
https://www.ncbi.nlm.nih.gov/pubmed/23430986
http://dx.doi.org/10.2147/CIA.S38349
Descripción
Sumario:The ubiquitous distribution of vitamin D receptors in the human body is responsible for the pleiotropic effects of vitamin D-receptor activation. We discuss the possible beneficial effects of a selective activator of vitamin D receptor, paricalcitol, on the cardiovascular system in chronic heart failure patients and chronic kidney patients, in light of new trials. Paricalcitol should provide additional clinical benefits over the standard treatment for chronic kidney and heart failure, especially in cases of cardiorenal syndrome.

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