Functional α7β2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid β peptides

BACKGROUND: β-amyloid (Aβ) accumulation is described as a hallmark of Alzheimer’s disease (AD). Aβ perturbs a number of synaptic components including nicotinic acetylcholine receptors containing α7 subunits (α7-nAChRs), which are abundantly expressed in the hippocampus and found on GABAergic interne...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Qiang, Huang, Yao, Shen, Jianxin, Steffensen, Scott, Wu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573893/
https://www.ncbi.nlm.nih.gov/pubmed/23272676
http://dx.doi.org/10.1186/1471-2202-13-155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573893/
https://www.ncbi.nlm.nih.gov/pubmed/23272676
http://dx.doi.org/10.1186/1471-2202-13-155

Ejemplares similares