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Insulin resistance and adiponectin levels are associated with height catch-up growth in pre-pubertal Chinese individuals born small for gestational age

ABSTRACTS: BACKGROUND AND OBJECTIVE: The study was performed to determine whether catch-up growth is associated with the development of insulin resistance and to explore serum endocrine markers associated with the metabolism of adipose tissue in a Chinese population born small for gestational age(SG...

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Autores principales: Deng, Hong-Zhu, Deng, Hong, Su, Zhe, Li, Yan-Hong, Ma, Hua-Mei, Chen, Hong-Shan, Du, Min-Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574033/
https://www.ncbi.nlm.nih.gov/pubmed/23186039
http://dx.doi.org/10.1186/1743-7075-9-107
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author Deng, Hong-Zhu
Deng, Hong
Su, Zhe
Li, Yan-Hong
Ma, Hua-Mei
Chen, Hong-Shan
Du, Min-Lian
author_facet Deng, Hong-Zhu
Deng, Hong
Su, Zhe
Li, Yan-Hong
Ma, Hua-Mei
Chen, Hong-Shan
Du, Min-Lian
author_sort Deng, Hong-Zhu
collection PubMed
description ABSTRACTS: BACKGROUND AND OBJECTIVE: The study was performed to determine whether catch-up growth is associated with the development of insulin resistance and to explore serum endocrine markers associated with the metabolism of adipose tissue in a Chinese population born small for gestational age(SGA) SUBJECTS AND METHODS: We recruited 56 children born SGA with catch-up growth and 55 born without catch-up growth, who were further grouped into groups I (with BMI catch-up) and II (without BMI catch-up) respectively, as well as 52 children born appropriate for gestational age (AGA) with normal height. Their serum fasting insulin, fasting glucose, insulin-like growth factor-1, adiponectin, IGFBP-1, triglyceride concentrations, and the homeostasis assessment model for insulin resistance (HOMA-IR) were evaluated. RESULTS: (1) The HOMA-IR values in SGA-I with catch-up growth group were significantly higher than those in SGA-II with catch-up growth, SGA-I without catch-up growth and AGA children respectively. (2) The serum adiponectin levels of individuals in the SGA-I without catch-up growth and SGA-II with catch-up growth groups were significantly lower than those from the SGA-II without catch-up growth group. There was no difference in triglyceride or IGFBP-1 levels among the groups. (3) The degree of HOMA-IR was positively correlated with age, current BMI and △height SDS in SGA children. CONCLUSION: The development of insulin resistance and lower levels of adiponectin were closely correlated with higher BMI and the postnatal height catch-up growth in SGA children.
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spelling pubmed-35740332013-02-16 Insulin resistance and adiponectin levels are associated with height catch-up growth in pre-pubertal Chinese individuals born small for gestational age Deng, Hong-Zhu Deng, Hong Su, Zhe Li, Yan-Hong Ma, Hua-Mei Chen, Hong-Shan Du, Min-Lian Nutr Metab (Lond) Research ABSTRACTS: BACKGROUND AND OBJECTIVE: The study was performed to determine whether catch-up growth is associated with the development of insulin resistance and to explore serum endocrine markers associated with the metabolism of adipose tissue in a Chinese population born small for gestational age(SGA) SUBJECTS AND METHODS: We recruited 56 children born SGA with catch-up growth and 55 born without catch-up growth, who were further grouped into groups I (with BMI catch-up) and II (without BMI catch-up) respectively, as well as 52 children born appropriate for gestational age (AGA) with normal height. Their serum fasting insulin, fasting glucose, insulin-like growth factor-1, adiponectin, IGFBP-1, triglyceride concentrations, and the homeostasis assessment model for insulin resistance (HOMA-IR) were evaluated. RESULTS: (1) The HOMA-IR values in SGA-I with catch-up growth group were significantly higher than those in SGA-II with catch-up growth, SGA-I without catch-up growth and AGA children respectively. (2) The serum adiponectin levels of individuals in the SGA-I without catch-up growth and SGA-II with catch-up growth groups were significantly lower than those from the SGA-II without catch-up growth group. There was no difference in triglyceride or IGFBP-1 levels among the groups. (3) The degree of HOMA-IR was positively correlated with age, current BMI and △height SDS in SGA children. CONCLUSION: The development of insulin resistance and lower levels of adiponectin were closely correlated with higher BMI and the postnatal height catch-up growth in SGA children. BioMed Central 2012-11-28 /pmc/articles/PMC3574033/ /pubmed/23186039 http://dx.doi.org/10.1186/1743-7075-9-107 Text en Copyright ©2012 DENG et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Deng, Hong-Zhu
Deng, Hong
Su, Zhe
Li, Yan-Hong
Ma, Hua-Mei
Chen, Hong-Shan
Du, Min-Lian
Insulin resistance and adiponectin levels are associated with height catch-up growth in pre-pubertal Chinese individuals born small for gestational age
title Insulin resistance and adiponectin levels are associated with height catch-up growth in pre-pubertal Chinese individuals born small for gestational age
title_full Insulin resistance and adiponectin levels are associated with height catch-up growth in pre-pubertal Chinese individuals born small for gestational age
title_fullStr Insulin resistance and adiponectin levels are associated with height catch-up growth in pre-pubertal Chinese individuals born small for gestational age
title_full_unstemmed Insulin resistance and adiponectin levels are associated with height catch-up growth in pre-pubertal Chinese individuals born small for gestational age
title_short Insulin resistance and adiponectin levels are associated with height catch-up growth in pre-pubertal Chinese individuals born small for gestational age
title_sort insulin resistance and adiponectin levels are associated with height catch-up growth in pre-pubertal chinese individuals born small for gestational age
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574033/
https://www.ncbi.nlm.nih.gov/pubmed/23186039
http://dx.doi.org/10.1186/1743-7075-9-107
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