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Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes
BACKGROUND: Cyrtomium fortumei (J.) Smith is an important Chinese herbal medicine because of its biological functions. However, systematic and comprehensive studies on the phytochemicals from Cyrtomium fortumei (J.) Smith and their bioactivity are limited. RESULTS: Using the bioassay-guided techniqu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574041/ https://www.ncbi.nlm.nih.gov/pubmed/23379693 http://dx.doi.org/10.1186/1752-153X-7-24 |
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author | Yang, Shengjie Liu, Mingchuan Liang, Na Zhao, Qi Zhang, Yuping Xue, Wei Yang, Song |
author_facet | Yang, Shengjie Liu, Mingchuan Liang, Na Zhao, Qi Zhang, Yuping Xue, Wei Yang, Song |
author_sort | Yang, Shengjie |
collection | PubMed |
description | BACKGROUND: Cyrtomium fortumei (J.) Smith is an important Chinese herbal medicine because of its biological functions. However, systematic and comprehensive studies on the phytochemicals from Cyrtomium fortumei (J.) Smith and their bioactivity are limited. RESULTS: Using the bioassay-guided technique, the ethyl acetate and n-BuOH extracts of the rhizomes of Cyrtomium fortumei (J.) Smith were shown to exhibit good antitumor activities, consequently leading to the isolation of 23 compounds. All compounds were isolated from the plant for the first time. The inhibitory activities of these compounds were investigated on tumor cells MGC-803, PC3, and A375 in vitro by MTT (thiazolyl blue tetrazolium bromide) assay, and the results showed that pimpinellin (3) had potent cytotoxic activities against the three cell lines, with the IC(50) values of 14.4 ± 0.3 μM, 20.4 ± 0.5 μM, and 29.2 ± 0.6 μM, respectively. The mechanism of the antitumor action indicated that pimpinellin inhibited the growth of MGC-803 cells via the induction of tumor cell apoptosis, with apoptosis ratio of 27.44% after 72 h of treatment at 20 μM. CONCLUSIONS: This study suggests that most of the compounds from the roots of Cyrtomium fortumei (J.) Smith could inhibit the growth of human carcinoma cells. Moreover, pimpinellin inhibited the growth of tumor cells via the induction of tumor cell apoptosis. |
format | Online Article Text |
id | pubmed-3574041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35740412013-02-16 Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes Yang, Shengjie Liu, Mingchuan Liang, Na Zhao, Qi Zhang, Yuping Xue, Wei Yang, Song Chem Cent J Research Article BACKGROUND: Cyrtomium fortumei (J.) Smith is an important Chinese herbal medicine because of its biological functions. However, systematic and comprehensive studies on the phytochemicals from Cyrtomium fortumei (J.) Smith and their bioactivity are limited. RESULTS: Using the bioassay-guided technique, the ethyl acetate and n-BuOH extracts of the rhizomes of Cyrtomium fortumei (J.) Smith were shown to exhibit good antitumor activities, consequently leading to the isolation of 23 compounds. All compounds were isolated from the plant for the first time. The inhibitory activities of these compounds were investigated on tumor cells MGC-803, PC3, and A375 in vitro by MTT (thiazolyl blue tetrazolium bromide) assay, and the results showed that pimpinellin (3) had potent cytotoxic activities against the three cell lines, with the IC(50) values of 14.4 ± 0.3 μM, 20.4 ± 0.5 μM, and 29.2 ± 0.6 μM, respectively. The mechanism of the antitumor action indicated that pimpinellin inhibited the growth of MGC-803 cells via the induction of tumor cell apoptosis, with apoptosis ratio of 27.44% after 72 h of treatment at 20 μM. CONCLUSIONS: This study suggests that most of the compounds from the roots of Cyrtomium fortumei (J.) Smith could inhibit the growth of human carcinoma cells. Moreover, pimpinellin inhibited the growth of tumor cells via the induction of tumor cell apoptosis. BioMed Central 2013-02-04 /pmc/articles/PMC3574041/ /pubmed/23379693 http://dx.doi.org/10.1186/1752-153X-7-24 Text en Copyright ©2013 Yang et al.; licensee Chemistry Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yang, Shengjie Liu, Mingchuan Liang, Na Zhao, Qi Zhang, Yuping Xue, Wei Yang, Song Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes |
title | Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes |
title_full | Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes |
title_fullStr | Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes |
title_full_unstemmed | Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes |
title_short | Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes |
title_sort | discovery and antitumor activities of constituents from cyrtomium fortumei (j.) smith rhizomes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574041/ https://www.ncbi.nlm.nih.gov/pubmed/23379693 http://dx.doi.org/10.1186/1752-153X-7-24 |
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