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Biocidal activity of metalloacid-coated surfaces against multidrug-resistant microorganisms

BACKGROUND: The antimicrobial effects of a coating of molybdenum trioxide (MoO(3)) has been recently described. The metalloacid material produces oxonium ions (H(3)O(+)), which creates an acidic pH that is an effective, non specific antimicrobial. We determined the in vitro antimicrobial activity of...

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Autores principales: Tétault, Nathalie, Gbaguidi-Haore, Houssein, Bertrand, Xavier, Quentin, Roland, van der Mee-Marquet, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574046/
https://www.ncbi.nlm.nih.gov/pubmed/23148568
http://dx.doi.org/10.1186/2047-2994-1-35
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author Tétault, Nathalie
Gbaguidi-Haore, Houssein
Bertrand, Xavier
Quentin, Roland
van der Mee-Marquet, Nathalie
author_facet Tétault, Nathalie
Gbaguidi-Haore, Houssein
Bertrand, Xavier
Quentin, Roland
van der Mee-Marquet, Nathalie
author_sort Tétault, Nathalie
collection PubMed
description BACKGROUND: The antimicrobial effects of a coating of molybdenum trioxide (MoO(3)) has been recently described. The metalloacid material produces oxonium ions (H(3)O(+)), which creates an acidic pH that is an effective, non specific antimicrobial. We determined the in vitro antimicrobial activity of molybdenum trioxide metalloacid-coated surfaces. METHODS: Metalloacid-coated and non-coated (control) surfaces were contaminated by exposing them for 15 minutes to microbial suspensions containing 10(5) cfu/mL. Eleven microorganisms responsible for nosocomial infections were tested: two Staphylococcus aureus strains (the hetero-vancomycin intermediate MRSA Mu50 strain and a ST80-PVL-producing MRSA strain); a vancomycin-resistant vanA Enterococcus faecium strain; three extended-spectrum beta-lactamase-producing Enterobacteriaceae strains; a MBL-producing Pseudomonas aeruginosa strain; a multidrug-resistant Acinetobacter baumannii strain; a toxin-producing Clostridium difficile strain; and two fungi (Candida albicans and Aspergillus fumigatus). The assay tested the ability of the coated surfaces to kill microorganisms. RESULTS: Against all non-sporulating microorganisms tested, metalloacid-coated surfaces exhibited significant antimicrobial activity relative to that of the control surfaces within two to six hours after contact with the microorganisms (p < 0.001). Microorganism survival on the coated surfaces was greatly impaired, whereas microorganism survival on control surfaces remained substantial. CONCLUSIONS: We suggest that, facing the continuing shedding of microorganisms in the vicinity of colonized or infected patients, the continuous biocidal effect of hydroxonium oxides against multidrug-resistant microorganisms may help limit environmental contamination between consecutive cleaning procedures.
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spelling pubmed-35740462013-02-16 Biocidal activity of metalloacid-coated surfaces against multidrug-resistant microorganisms Tétault, Nathalie Gbaguidi-Haore, Houssein Bertrand, Xavier Quentin, Roland van der Mee-Marquet, Nathalie Antimicrob Resist Infect Control Research BACKGROUND: The antimicrobial effects of a coating of molybdenum trioxide (MoO(3)) has been recently described. The metalloacid material produces oxonium ions (H(3)O(+)), which creates an acidic pH that is an effective, non specific antimicrobial. We determined the in vitro antimicrobial activity of molybdenum trioxide metalloacid-coated surfaces. METHODS: Metalloacid-coated and non-coated (control) surfaces were contaminated by exposing them for 15 minutes to microbial suspensions containing 10(5) cfu/mL. Eleven microorganisms responsible for nosocomial infections were tested: two Staphylococcus aureus strains (the hetero-vancomycin intermediate MRSA Mu50 strain and a ST80-PVL-producing MRSA strain); a vancomycin-resistant vanA Enterococcus faecium strain; three extended-spectrum beta-lactamase-producing Enterobacteriaceae strains; a MBL-producing Pseudomonas aeruginosa strain; a multidrug-resistant Acinetobacter baumannii strain; a toxin-producing Clostridium difficile strain; and two fungi (Candida albicans and Aspergillus fumigatus). The assay tested the ability of the coated surfaces to kill microorganisms. RESULTS: Against all non-sporulating microorganisms tested, metalloacid-coated surfaces exhibited significant antimicrobial activity relative to that of the control surfaces within two to six hours after contact with the microorganisms (p < 0.001). Microorganism survival on the coated surfaces was greatly impaired, whereas microorganism survival on control surfaces remained substantial. CONCLUSIONS: We suggest that, facing the continuing shedding of microorganisms in the vicinity of colonized or infected patients, the continuous biocidal effect of hydroxonium oxides against multidrug-resistant microorganisms may help limit environmental contamination between consecutive cleaning procedures. BioMed Central 2012-11-14 /pmc/articles/PMC3574046/ /pubmed/23148568 http://dx.doi.org/10.1186/2047-2994-1-35 Text en Copyright ©2012 Tétault et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Tétault, Nathalie
Gbaguidi-Haore, Houssein
Bertrand, Xavier
Quentin, Roland
van der Mee-Marquet, Nathalie
Biocidal activity of metalloacid-coated surfaces against multidrug-resistant microorganisms
title Biocidal activity of metalloacid-coated surfaces against multidrug-resistant microorganisms
title_full Biocidal activity of metalloacid-coated surfaces against multidrug-resistant microorganisms
title_fullStr Biocidal activity of metalloacid-coated surfaces against multidrug-resistant microorganisms
title_full_unstemmed Biocidal activity of metalloacid-coated surfaces against multidrug-resistant microorganisms
title_short Biocidal activity of metalloacid-coated surfaces against multidrug-resistant microorganisms
title_sort biocidal activity of metalloacid-coated surfaces against multidrug-resistant microorganisms
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574046/
https://www.ncbi.nlm.nih.gov/pubmed/23148568
http://dx.doi.org/10.1186/2047-2994-1-35
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