The TRPM6/EGF Pathway Is Downregulated in a Rat Model of Cisplatin Nephrotoxicity

Cisplatin-induced hypomagnesemia is described in humans and rats, but the underlying mechanisms are still unclear. Recent studies have shown that epidermal growth factor (EGF) stimulates Mg(2+) re-absorption in the distal convoluted tubule via the Mg(2+) channel TRPM6. This study investigates the ro...

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Detalles Bibliográficos
Autores principales: Ledeganck, Kristien J., Boulet, Gaëlle A., Bogers, Johannes J., Verpooten, Gert A., De Winter, Benedicte Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574071/
https://www.ncbi.nlm.nih.gov/pubmed/23457647
http://dx.doi.org/10.1371/journal.pone.0057016

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