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Amide Proton Solvent Protection in Amylin Fibrils Probed by Quenched Hydrogen Exchange NMR
Amylin is an endocrine hormone that accumulates in amyloid plaques in patients with advanced type 2 diabetes. The amyloid plaques have been implicated in the destruction of pancreatic β-cells, which synthesize amylin and insulin. To better characterize the secondary structure of amylin in amyloid fi...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574092/ https://www.ncbi.nlm.nih.gov/pubmed/23457571 http://dx.doi.org/10.1371/journal.pone.0056467 |